iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane

Stable Identifier
Reaction [omitted]
Homo sapiens
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In mice, inactive rhomboid protein 2 (iRHOM2) has been shown to be required for disintegrin and metalloproteinase domain-containing protein 17's (ADAM17) exit from the ER (Cavadas et al. 2017), through the trans-Golgi network and on to the plasma membrane (Adrain et al. 2012, McIlwain et al. 2012, Issuree et al. 2013, Cavadas et al. 2017).
Literature References
PubMed ID Title Journal Year
22246777 Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

Taylor, N, Zettl, M, Christova, Y, Freeman, M, Adrain, C

Science 2012
29045841 Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cavadas, M, Gaspar, CJ, Hu, T, Badenes, M, Gerner, C, Bileck, A, Félix, I, Bolado, A, von Kriegsheim, A, Domingos, PM, Burbridge, E, Oikonomidi, I, Adrain, C

Cell Rep 2017
22246778 iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

Blobel, CP, Duncan, G, McIlwain, DR, Berger, T, Mak, TW, Hamada, K, Ohashi, PS, Maney, SK, Itie-Youten, A, Murthy, A, Ohishi, K, Wakeham, A, Khokha, R, Häussinger, D, Lang, KS, Maretzky, T, Lang, PA, Xu, HC

Science 2012
Catalyst Activity

protein transporter activity of iRHOM2 [Golgi lumen]

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