FURIN cleaves ADAM17

Stable Identifier
Reaction [transition]
Homo sapiens
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Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) is a type I transmembrane protein that consist of an N-terminal signal sequence followed by a prodomain, a metalloproteinase (catalytic) domain, a disintegrin domain, an EGF-like (cysteine-rich) domain, a single transmembrane domain and a cytoplasmic domain (Scheller et al. 2011, Lambrecht et al. 2018). While ADAM17 is being transported through the trans-Golgi network, FURIN cleaves the prodomain region of ADAM17 releasing the inhibitory part (Milla et al. 1999, Gonzales et al. 2004, Wong et al. 2015) and leaving the catalytically-active form (ADAM17(215-827) (Srour et al. 2003, Endres et al. 2003, Adrain et al. 2012, McIlwain et al. 2012, Wong et al. 2015).
Literature References
PubMed ID Title Journal Year
25795784 The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

Blobel, CP, Peleg, Y, Maretzky, T, Wong, E, Sagi, I

J. Biol. Chem. 2015
22246777 Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

Taylor, N, Zettl, M, Christova, Y, Freeman, M, Adrain, C

Science 2012
22246778 iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

Blobel, CP, Duncan, G, McIlwain, DR, Berger, T, Mak, TW, Hamada, K, Ohashi, PS, Maney, SK, Itie-Youten, A, Murthy, A, Ohishi, K, Wakeham, A, Khokha, R, Häussinger, D, Lang, KS, Maretzky, T, Lang, PA, Xu, HC

Science 2012
12755693 Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation

Postina, R, Anders, A, Endres, K, Fahrenholz, F, Gilbert, S, Kojro, E

Eur. J. Biochem. 2003
14623079 TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity

Lebel, A, Day, R, Fugère, M, Fournier, I, Dubois, CM, McMahon, S, Srour, N

FEBS Lett. 2003
Catalyst Activity

serine-type endopeptidase activity of FURIN [Golgi membrane]

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