CD163 gene produces CD163 protein

Stable Identifier
R-HSA-9662781
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, nucleolus
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CD163 gene produces CD163 protein
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The CD163 gene encodes scavenger receptor cysteine-rich type 1 protein M130 (CD163) which functions at the plasma membrane of macrophages (Etzerodt & Moestrup 2013). Glucocorticoid, interleukin (IL)-6 and IL-10 are some of the most potent stimulators of CD163 expression (Petra Högger et al. 1998, P Högger et al. 1998, Van den Heuvel et al. 1999, Buechler et al. 2000 & Sulahian et al. 2000, ). For simplicity, the steps involed in transcription and translation have been omitted.

Literature References
PubMed ID Title Journal Year
10648003 Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli

Buechler, C, Ritter, M, Orsó, E, Langmann, T, Klucken, J, Schmitz, G

J. Leukoc. Biol. 2000
10975989 Human monocytes express CD163, which is upregulated by IL-10 and identical to p155

Sulahian, TH, Högger, P, Wahner, AE, Wardwell, K, Goulding, NJ, Sorg, C, Droste, A, Stehling, M, Wallace, PK, Morganelli, PM, Guyre, PM

Cytokine 2000
9523318 Biochemical characterization of a glucocorticoid-induced membrane protein (RM3/1) in human monocytes and its application as model system for ranking glucocorticoid potency

Högger, P, Erpenstein, U, Rohdewald, P, Sorg, C

Pharm. Res. 1998
8921966 Identification of a novel surface molecule, RM3/1, that contributes to the adhesion of glucocorticoid-induced human monocytes to endothelial cells

Wenzel, I, Roth, J, Sorg, C

Eur. J. Immunol. 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
Glucocorticoid, IL6, IL10 [extracellular region] (Homo sapiens)
Summation

Macrophages stimulated with glucocorticoid, IL6 and IL10 overexpress CD163 molecule

Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-09-24)
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