ADAM17 binds Zn2+

Stable Identifier
R-HSA-9662773
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A crystallography study revealed that disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) requires Zinc as a cofactor to function properly (Maskos et al. 1998).

Literature References
PubMed ID Title Journal Year
9520379 Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme

Maskos, K, Fernandez-Catalan, C, Huber, R, Bourenkov, GP, Bartunik, H, Ellestad, GA, Reddy, P, Wolfson, MF, Rauch, CT, Castner, BJ, Davis, R, Clarke, HR, Petersen, M, Fitzner, JN, Cerretti, DP, March, CJ, Paxton, RJ, Black, RA, Bode, W

Proc. Natl. Acad. Sci. U.S.A. 1998
Participants
Participant Of
Authored
Reviewed
Created
Cite Us!