iRHOM2 transports ADAM17 from ER to the Golgi-network

Stable Identifier
R-HSA-9662747
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In mice, inactive rhomboid protein 2 (iRHOM2) has been shown to be required for disintegrin and metalloproteinase domain-containing protein 17's (ADAM17) exit from the ER (Cavadas et al. 2017), through the trans-Golgi network and on to the plasma membrane (Adrain et al. 2012, McIlwain et al. 2012, Issuree et al. 2013, Cavadas et al. 2017).

Literature References
PubMed ID Title Journal Year
29045841 Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cavadas, M, Oikonomidi, I, Gaspar, CJ, Burbridge, E, Badenes, M, Félix, I, Bolado, A, Hu, T, Bileck, A, Gerner, C, Domingos, PM, von Kriegsheim, A, Adrain, C

Cell Rep 2017
22246777 Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

Adrain, C, Zettl, M, Christova, Y, Taylor, N, Freeman, M

Science 2012
22246778 iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

McIlwain, DR, Lang, PA, Maretzky, T, Hamada, K, Ohishi, K, Maney, SK, Berger, T, Murthy, A, Duncan, G, Xu, HC, Lang, KS, Häussinger, D, Wakeham, A, Itie-Youten, A, Khokha, R, Ohashi, PS, Blobel, CP, Mak, TW

Science 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein transporter activity of iRHOM2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Authored
Reviewed
Created
Cite Us!