IL6 gene produces IL6 protein

Stable Identifier
R-HSA-9662710
Type
Reaction [omitted]
Species
Homo sapiens
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The gene for IL-6 is located at chromosome 7 whose unit transcription consists of 5 exons and 4 introns. The promoter region contains several transcription start sites with response elements for nuclear factor (NF)-κB, enhancer-binding protein beta (C/EPBβ; formerly NF-IL6), activator protein (AP)-1 (Burger 2013) and CREB transcription factor (Dendorfer et al. 1994). The protein form of human IL-6 is a glycoprotein composed of 184 amino acids with a molecular weight of 21-28 kDa, depending on its degree of glycosylation. It has a 4-helix bundle structure made up of 4 long α-helices arranged in an up-up-down-down topology (Burger 2013).

Literature References
PubMed ID Title Journal Year
8007951 Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide

Dendorfer, U, Oettgen, P, Libermann, TA

Mol. Cell. Biol. 1994
24273487 Impact of interleukin-6 in hematological malignancies

Burger, R

Transfus Med Hemother 2013
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