The IL-6 promoter contains several transcription factor-responsive elements (Luo and Zheng 2016). CREB, a classical cAMP-inducible CRE-binding factor interacts with a region of the IL-6 promoter that is known as CRE-like sequence (Dendorfer et al. 1994). Moreover, IL-6 is a pleiotropic cytokine produced by a wide variety of cells including macrophages, T cells, B cells, fibroblasts, and endothelial cells (Yang et al. 2014).