CREB binds IL6 promoter

Stable Identifier
R-HSA-9662708
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The IL-6 promoter contains several transcription factor-responsive elements (Luo and Zheng 2016). CREB, a classical cAMP-inducible CRE-binding factor interacts with a region of the IL-6 promoter that is known as CRE-like sequence (Dendorfer et al. 1994). Moreover, IL-6 is a pleiotropic cytokine produced by a wide variety of cells including macrophages, T cells, B cells, fibroblasts, and endothelial cells (Yang et al. 2014).

Literature References
PubMed ID Title Journal Year
8007951 Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide

Dendorfer, U, Oettgen, P, Libermann, TA

Mol. Cell. Biol. 1994
24519125 Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells

Yang, R, Lin, Q, Gao, HB, Zhang, P

Braz. J. Med. Biol. Res. 2014
28066415 Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms

Luo, Y, Zheng, SG

Front Immunol 2016
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