Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ESPN [cytosol]
Stable Identifier
R-HSA-9662418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Espin, ESPN_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
ESPN [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Outer hair cell stereocilium tip [cytosol] (Homo sapiens)
ESPN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:B1AK53 ESPN
Gene Names
ESPN, DFNB36, LP2654
Chain
chain:1-854
Reference Genes
BioGPS Gene:83715 ESPN
COSMIC (genes):ESPN ESPN
CTD Gene:83715 ESPN
dbSNP Gene:83715 ESPN
ENSEMBL:ENSG00000187017 ESPN
HGNC:13281 ESPN
Monarch:83715 ESPN
NCBI Gene:83715 ESPN
OMIM:606351 ESPN
UCSC:B1AK53 ESPN
Reference Transcript
RefSeq:NM_031475.2 ESPN
Other Identifiers
11731179_s_at
16658390
223549_PM_s_at
223549_s_at
2318258
2318259
2318260
2318261
2318263
2318264
2318265
2318266
2318267
2318271
2318273
2318274
2318275
2318276
2318277
2318278
2318279
2318280
2318281
2318282
2318283
2318284
2318285
2318286
2318287
2318291
2318292
2318293
2318294
2318295
2318296
2318297
2318298
2318299
2318300
2318301
2318302
2318303
2318304
2318305
2318306
2318307
2318308
2318309
2318310
2318311
2318312
2318313
2318314
233979_PM_s_at
233979_s_at
2398454
2398456
2398457
2398463
2398465
2398466
2398468
2398469
2398472
2398476
2398479
2398481
2398484
2398485
2398490
2398491
2398492
2398493
2398494
2398553
2398555
2398556
2398560
242327_PM_x_at
242327_x_at
78182_at
7897288
83025_at
83715
A_14_P104725
A_23_P12405
GE474395
GE83257
GO:0003779
GO:0005515
GO:0005737
GO:0005856
GO:0005902
GO:0005903
GO:0007605
GO:0008092
GO:0017124
GO:0030034
GO:0031941
GO:0032420
GO:0032426
GO:0042995
GO:0043226
GO:0050877
GO:0051015
GO:0051017
HMNXSV003003417
HMNXSV003056551
Hs.147953.0.A1_3p_at
Hs.147953.0.A1_3p_x_at
Hs.251216.1.A1_3p_x_at
ILMN_1806710
PH_hs_0026860
TC01000088.hg
g12053260_3p_a_at
Participates
as a component of
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
Outer hair cell stereocilium tip [cytosol] (Homo sapiens)
Cross References
ENSEMBL
ENSP00000496593
,
ENST00000645284
,
ENST00000461727
,
ENSP00000465308
OpenTargets
ENSG00000187017
HPA
ENSG00000187017-ESPN
PRO
B1AK53
Pharos - Targets
B1AK53
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text