SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

Stable Identifier
R-HSA-9661799
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The organic anion transporting polypeptide (SLCO1B3, aka OATP-8, LST2, SLC21A8), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (van de Steeg et al. 2012).

Literature References
PubMed ID Title Journal Year
22232210 Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

van de Steeg, E, Stranecký, V, Hartmannová, H, Nosková, L, Hřebíček, M, Wagenaar, E, van Esch, A, de Waart, DR, Oude Elferink, RP, Kenworthy, KE, Sticová, E, al-Edreesi, M, Knisely, AS, Kmoch, S, Jirsa, M, Schinkel, AH

J. Clin. Invest. 2012
Participants
Output
Participates
Catalyst Activity

sodium-independent organic anion transmembrane transporter activity of SLCO1B3 [plasma membrane]

Orthologous Events
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