An unknown BILR reduces BIL to D-UBGN

Stable Identifier
Reaction [uncertain]
Homo sapiens
Related Species
Clostridium perfringens
Locations in the PathwayBrowser
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Microbes present in the large intestine reduce bilirubin (BIL) to D-urobilinogen (D-UBGN) (Troxler et al. 1968, Watson et al. 1958, Vitek et al. 2006). The identity of the bilirubin reductase (BILR) is unknown (Koníčková et al. 2012). Some D-UBGN can be reabsorbed into the portal circulation and delivered to the liver where it is recycled back into the biliary flow.
Literature References
PubMed ID Title Journal Year
5652509 Synthesis of urobilinogen by broken cell preparations of intestinal bacteria

Dawber, NH, Troxler, RF, Lester, R

Gastroenterology 1968
13591316 Preferential reduction of conjugated bilirubin to urobilinogen by normal fecal flora

LOWRY, PT, Watson, CJ, Campbell, M

Proc. Soc. Exp. Biol. Med. 1958
16504607 Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal flora

Muchová, L, Ubik, K, Majer, F, Malina, J, Branný, P, Zelenka, J, Vítek, L, Jirásková, A

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006
22540115 Reduction of bilirubin ditaurate by the intestinal bacterium Clostridium perfringens

Lešetický, L, Konícková, R, Vítek, L, Štícha, M, Zelenka, J, Jirásková, A

Acta Biochim. Pol. 2012
Catalyst Activity

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor of BILR [extracellular region]

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