An unknown BILR reduces BIL to D-UBGN

Stable Identifier
R-HSA-9661745
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Clostridium perfringens
Compartment
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Microbes present in the large intestine reduce bilirubin (BIL) to D-urobilinogen (D-UBGN) (Troxler et al. 1968, Watson et al. 1958, Vitek et al. 2006). The identity of the bilirubin reductase (BILR) is unknown (Koníčková et al. 2012). Some D-UBGN can be reabsorbed into the portal circulation and delivered to the liver where it is recycled back into the biliary flow.

Literature References
PubMed ID Title Journal Year
13591316 Preferential reduction of conjugated bilirubin to urobilinogen by normal fecal flora

Watson, CJ, Campbell, M, LOWRY, PT

Proc. Soc. Exp. Biol. Med. 1958
5652509 Synthesis of urobilinogen by broken cell preparations of intestinal bacteria

Troxler, RF, Dawber, NH, Lester, R

Gastroenterology 1968
16504607 Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal flora

Vítek, L, Majer, F, Muchová, L, Zelenka, J, Jirásková, A, Branný, P, Malina, J, Ubik, K

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006
22540115 Reduction of bilirubin ditaurate by the intestinal bacterium Clostridium perfringens

Konícková, R, Jirásková, A, Zelenka, J, Lešetický, L, Štícha, M, Vítek, L

Acta Biochim. Pol. 2012
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor of BILR [extracellular region]
Physical Entity
Activity
Authored
Reviewed
Created
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