An unknown reductase reduces D-UBGN to STBN

Stable Identifier
R-HSA-9661726
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Clostridium perfringens
Compartment
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General
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The D-urobilinogen (D-UBGN) that remains in the intestine is directly reduced to stercobilin (STBN) by unknown bacterial reductases. Stercobilins oxidize to form brownish pigments which lead to the characteristic brown colour found in normal feces (Vitek et al. 2006). STBN can also be reduced to stercobilinogen (L-urobilinogen), which can then be further oxidized to STBN. This constitutes the "enterohepatic urobilinogen cycle."

Literature References
PubMed ID Title Journal Year
16504607 Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal flora

Vítek, L, Majer, F, Muchová, L, Zelenka, J, Jirásková, A, Branný, P, Malina, J, Ubik, K

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor of UBGNR [extracellular region]
Physical Entity
Activity
Authored
Reviewed
Created
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