BMG, BDG translocates from ER lumen to cytosol

Stable Identifier
R-HSA-9661446
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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BMG, BDG translocates from ER lumen to cytosol
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To be excreted from the cell, mono- and di-glucuronated bilirubin (BMG, BDG respectively) translocate from the ER lumen to the cytosol. Glucuronated bilirubin is a much more hydrophilic substance than bilirubin so the assumption is some form of active transport is required for this translocation. No transporter has been identified yet but tentatively, we assign the name bilirubin glucuronide efflux transporter (BGET) (Erlinger et al. 2014, Rowland et al. 2013).
Literature References
PubMed ID Title Journal Year
23500526 The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification

Rowland, A, Miners, JO, Mackenzie, PI

Int. J. Biochem. Cell Biol. 2013
24704527 Inherited disorders of bilirubin transport and conjugation: new insights into molecular mechanisms and consequences

Erlinger, S, Arias, IM, Dhumeaux, D

Gastroenterology 2014
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Output
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Catalyst Activity

secondary active transmembrane transporter activity of BGET [endoplasmic reticulum membrane]

Physical Entity
BGET [endoplasmic reticulum membrane] (Homo sapiens)
Activity
secondary active transmembrane transporter activity (GO:0015291)
Cross References
RHEA
Authored
Jassal, B  (2019-09-16)
Reviewed
D'Eustachio, P  (2019-10-03)
Created
Jassal, B  (2019-09-16)
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