To be excreted from the cell, mono- and di-glucuronated bilirubin (BMG, BDG respectively) translocate from the ER lumen to the cytosol. Glucuronated bilirubin is a much more hydrophilic substance than bilirubin so the assumption is some form of active transport is required for this translocation. No transporter has been identified yet but tentatively, we assign the name bilirubin glucuronide efflux transporter (BGET) (Erlinger et al. 2014, Rowland et al. 2013).
Miners, JO, Rowland, A, Mackenzie, PI
Erlinger, S, Dhumeaux, D, Arias, IM
sodium-independent organic anion transmembrane transporter activity of BGET [endoplasmic reticulum membrane]
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