Reactome | BIL binds ALB

BIL binds ALB

Stable Identifier

R-HSA-9661432

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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The serum protein albumin (ALB) binds unconjugated bilirubin (BIL), preventing BIL toxicity (Griffiths et al. 1975, Weisiger et al. 2001). ALB-bound BIL is a water-soluble complex and is transported to the liver where it is selectively absorbed by hepatocytes.

Literature References

PubMed ID	Title	Journal	Year
1157293	The albumin binding of unconjugated bilirubin in serum Diamond, I, Dextraze, P, Griffiths, WC	Clin. Biochem.	1975
11397817	Affinity of human serum albumin for bilirubin varies with albumin concentration and buffer composition: results of a novel ultrafiltration method Weisiger, RA, Webster, CC, Ostrow, JD, Tiribelli, C, Pascolo, L, Mukerjee, P, Koehler, RK	J. Biol. Chem.	2001