BIL binds ALB

Stable Identifier
R-HSA-9661432
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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BIL binds ALB
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The serum protein albumin (ALB) binds unconjugated bilirubin (BIL), preventing BIL toxicity (Griffiths et al. 1975, Weisiger et al. 2001). ALB-bound BIL is a water-soluble complex and is transported to the liver where it is selectively absorbed by hepatocytes.
Literature References
PubMed ID Title Journal Year
1157293 The albumin binding of unconjugated bilirubin in serum

Griffiths, WC, Diamond, I, Dextraze, P

Clin. Biochem. 1975
11397817 Affinity of human serum albumin for bilirubin varies with albumin concentration and buffer composition: results of a novel ultrafiltration method

Weisiger, RA, Ostrow, JD, Koehler, RK, Webster, CC, Mukerjee, P, Pascolo, L, Tiribelli, C

J. Biol. Chem. 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

molecular carrier activity of ALB [extracellular region]

Physical Entity
ALB [extracellular region] (Homo sapiens)
Activity
molecular carrier activity (GO:0140104)
Orthologous Events
BIL binds ALB (Bos taurus)
BIL binds ALB (Canis familiaris)
BIL binds ALB (Gallus gallus)
BIL binds ALB (Mus musculus)
BIL binds ALB (Rattus norvegicus)
BIL binds ALB (Sus scrofa)
BIL binds ALB (Xenopus tropicalis)
Authored
Jassal, B  (2019-09-16)
Reviewed
D'Eustachio, P  (2019-10-03)
Somers, J  (2021-01-23)
Hill, DP  (2025-06-16)
Created
Jassal, B  (2019-09-16)
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