BIL:ALB dissociates

Stable Identifier
R-HSA-9661425
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BIL:ALB dissociates
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
When the bilirubin-albumin complex (BIL:ALB) reaches the liver, the highly permeable hepatic circulation facilitates the complex to reach the sinusoidal side of the hepatocyte. The exact mechanism of unbound BIL uptake is unclear but may proceed like this. BIL in complex with ALB is reversible and a tiny fraction of of free BIL is present in plasma in equilibrium with BIL:ALB. Hence this free BIL may be taken up at a rate determined by its plasma concentration. As free BIL is taken up, more BIL is released from ALB and becomes available for uptake (Bhagavan & Ha 2015).
Literature References
PubMed ID Title Journal Year
  Essentials of Medical Biochemistry (Second Edition)

Ha, CE, Bhagavan, NV

  2015
11134001 Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

Cui, Y, König, J, Buchholz, U, Leier, I, Keppler, D

J. Biol. Chem. 2001
Participants
Input
Output
Participates
as an event of
Orthologous Events
BIL:ALB dissociates (Bos taurus)
BIL:ALB dissociates (Canis familiaris)
BIL:ALB dissociates (Gallus gallus)
BIL:ALB dissociates (Mus musculus)
BIL:ALB dissociates (Rattus norvegicus)
BIL:ALB dissociates (Sus scrofa)
BIL:ALB dissociates (Xenopus tropicalis)
Authored
Jassal, B  (2019-09-16)
Reviewed
D'Eustachio, P  (2019-10-03)
Created
Jassal, B  (2019-09-16)
Cite Us!