ALB binds extracellular heme

Stable Identifier
R-HSA-9661419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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ALB binds extracellular heme
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Circulating free heme is cytotoxic. Binding of albumin (ALB) to heme protects cells from this potential toxicity. Heme transported out of cells by ABCG2 may be directly transferred from the transport protein onto HSA (human serum albumin (Desuzinges-Mandon et al. 2010), while heme transported by FLVCR1-1 may initially associated with lipoproteins before transfer to HSA (De Simone et al. 2023).
Literature References
PubMed ID Title Journal Year
36979511 Heme Scavenging and Delivery: The Role of Human Serum Albumin

De Simone, G, Varricchio, R, Ruberto, TF, di Masi, A, Ascenzi, P

Biomolecules 2023
20705604 ABCG2 transports and transfers heme to albumin through its large extracellular loop

Desuzinges-Mandon, E, Arnaud, O, Martinez, L, Huché, F, Di Pietro, A, Falson, P

J. Biol. Chem. 2010
Participants
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Output
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as an event of
Catalyst Activity

heme binding activity of ALB [extracellular region]

Physical Entity
ALB [extracellular region] (Homo sapiens)
Activity
heme binding (GO:0020037)
Orthologous Events
ALB binds extracellular heme (Bos taurus)
ALB binds extracellular heme (Canis familiaris)
ALB binds extracellular heme (Gallus gallus)
ALB binds extracellular heme (Mus musculus)
ALB binds extracellular heme (Rattus norvegicus)
ALB binds extracellular heme (Sus scrofa)
ALB binds extracellular heme (Xenopus tropicalis)
Authored
Jassal, B  (2019-09-16)
Reviewed
D'Eustachio, P  (2019-10-03)
Hill, DP  (2025-08-13)
Created
Jassal, B  (2019-09-16)
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