FLVCR1-2 transports heme from mitochondrial matrix to cytosol

Stable Identifier
R-HSA-9661408
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Feline leukemia virus subgroup C receptor-related protein 1 isoform 2 (FLVCR1-2), located on the mitochondrial membrane of all hematopoietic tissues, is a heme transporter that mediates heme efflux from the mitochondrion to the cytosol (Chiabrando et al. 2012). Silencing of FLVCR1-2 causes mitochondrial heme accumulation and termination of erythroid differentiation.

Literature References
PubMed ID Title Journal Year
23187127 The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

Chiabrando, D, Marro, S, Mercurio, S, Giorgi, C, Petrillo, S, Vinchi, F, Fiorito, V, Fagoonee, S, Camporeale, A, Turco, E, Merlo, GR, Silengo, L, Altruda, F, Pinton, P, Tolosano, E

J. Clin. Invest. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
heme transporter activity of FLVCR1-2 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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