Reactome | FLVCR1-2 transports heme from mitochondrial matrix to cytosol

FLVCR1-2 transports heme from mitochondrial matrix to cytosol

Stable Identifier

R-HSA-9661408

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix, mitochondrial inner membrane

Synonyms

heme b(in) = heme b(out)

ReviewStatus

5/5

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FLVCR1-2 transports heme from mitochondrial matrix to cytosol

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Feline leukemia virus subgroup C receptor-related protein 1 isoform 2 (FLVCR1-2), located on the mitochondrial membrane of all hematopoietic tissues, is a heme transporter that mediates heme efflux from the mitochondrion to the cytosol (Chiabrando et al. 2012). Silencing of FLVCR1-2 causes mitochondrial heme accumulation and termination of erythroid differentiation.

Literature References

PubMed ID	Title	Journal	Year
23187127	The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation Chiabrando, D, Marro, S, Mercurio, S, Giorgi, C, Petrillo, S, Vinchi, F, Fiorito, V, Fagoonee, S, Camporeale, A, Turco, E, Merlo, GR, Silengo, L, Altruda, F, Pinton, P, Tolosano, E	J. Clin. Invest.	2012