ABCC1 transports BIL from cytosol to extracellular region (blood)

Stable Identifier
R-HSA-9661405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Bilirubin (BIL), formed in erythroid cells, exits the cell to be transported to the liver for conjugation and ultimately, excretion. BIL possibly leaves the cell by simple diffusion as it is highly lipophilic (Kamisako et al. 2000). However, the multidrug resistance-associated protein 1 (ABCC1 aka MRP1) is known to mediate the ATP-dependent export of organic anions and drugs from cells. Unconjugated bilirubin (BIL) may also be exported from cells by ABCC1 (Rigato et al. 2004).

Literature References
PubMed ID Title Journal Year
11023036 Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance

Kamisako, T, Kobayashi, Y, Takeuchi, K, Ishihara, T, Higuchi, K, Tanaka, Y, Gabazza, EC, Adachi, Y

J. Gastroenterol. 2000
15245331 The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin

Rigato, I, Pascolo, L, Fernetti, C, Ostrow, JD, Tiribelli, C

Biochem. J. 2004
Participants
Participates
Catalyst Activity

ABC-type transporter activity of ABCC1 [plasma membrane]

Orthologous Events
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