Reactome | ABCC1 transports BIL from cytosol to extracellular region (blood)

ABCC1 transports BIL from cytosol to extracellular region (blood)

Stable Identifier

R-HSA-9661405

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region

ReviewStatus

5/5

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ABCC1 transports BIL from cytosol to extracellular region (blood)

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Bilirubin (BIL), formed in erythroid cells, exits the cell to be transported to the liver for conjugation and ultimately, excretion. BIL possibly leaves the cell by simple diffusion as it is highly lipophilic (Kamisako et al. 2000). However, the multidrug resistance-associated protein 1 (ABCC1 aka MRP1) is known to mediate the ATP-dependent export of organic anions and drugs from cells. Unconjugated bilirubin (BIL) may also be exported from cells by ABCC1 (Rigato et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15245331	The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin Ostrow, JD, Fernetti, C, Tiribelli, C, Rigato, I, Pascolo, L	Biochem. J.	2004
11023036	Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance Takeuchi, K, Gabazza, EC, Kamisako, T, Adachi, Y, Ishihara, T, Kobayashi, Y, Higuchi, K, Tanaka, Y	J. Gastroenterol.	2000