Reactome | RB1 T738_R775del [nucleoplasm]

RB1 T738_R775del [nucleoplasm]

Stable Identifier

R-HSA-9661042

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RB1 Thr738_Arg775del, RB1 delEx22

Icon

Locations in the PathwayBrowser for interactor UniProt:Q15329 E2F5

Expand all

Literature References

PubMed ID	Title	Journal	Year
15469821	An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant Ji, P, Rekhtman, K, Pagano, M, Bloom, J, Jiang, H, Zhu, L, Ichetovkin, M	Mol. Cell	2004
8413249	Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein Fattaey, A, Harlow, E, Helin, K	Mol. Cell. Biol.	1993
1826560	Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering Park, SH, Weinberg, RA, Lanier, L, Templeton, DJ	Proc. Natl. Acad. Sci. U.S.A.	1991
17187060	Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit Binné, UK, Kaelin, WG, Rape, M, Classon, MK, Wei, W, Dyson, NJ, Dick, FA, Näär, AM	Nat. Cell Biol.	2007

External Reference Information

External Reference

UniProt:P06400 RB1

Gene Names

RB1

Chain

initiator methionine:, chain:2-928

Reference Genes

BioGPS Gene:5925 RB1

COSMIC (genes):RB1 RB1

CTD Gene:5925 RB1

dbSNP Gene:5925 RB1

ENSEMBL:ENSG00000139687 RB1

ENSEMBL_homo_sapiens_GENE:ENSG00000139687.16 RB1

HGNC:9884 RB1

KEGG Gene (Homo sapiens):5925 RB1

Monarch:5925 RB1

NCBI Gene:5925 RB1

OMIM:614041 RB1

UCSC:P06400 RB1

Reference Transcript

RefSeq:NM_000321.2 RB1

Other Identifiers

11717702_a_at

11749112_a_at

11753684_a_at

1571_f_at

1672_f_at

16774690

1900_at

1905_s_at

203132_PM_at

203132_at

2044_s_at

211540_PM_s_at

211540_s_at

3489023

3489024

3489026

3489036

3489037

3489038

3489039

3489042

3489043

3489045

3489046

3489050

3489052

3489054

3489057

3489058

3489059

3489060

3489061

3489080

3489081

3489082

3489083

3489085

3489086

3489090

3489094

3489095

3489098

3489099

3489100

5925

7969017

A_14_P110907

A_14_P139049

A_23_P204850

GE57770

GO:0000082

GO:0000122

GO:0000278

GO:0000785

GO:0000977

GO:0001558

GO:0001894

GO:0002062

GO:0002376

GO:0003180

GO:0003677

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005819

GO:0005829

GO:0005856

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006469

GO:0006915

GO:0006954

GO:0007049

GO:0007059

GO:0007224

GO:0007265

GO:0007283

GO:0007346

GO:0008024

GO:0008283

GO:0008285

GO:0010629

GO:0012501

GO:0014009

GO:0016514

GO:0016605

GO:0019899

GO:0019900

GO:0022414

GO:0023052

GO:0030154

GO:0030182

GO:0030198

GO:0030308

GO:0031134

GO:0031175

GO:0031507

GO:0031625

GO:0032869

GO:0034088

GO:0034349

GO:0035189

GO:0035914

GO:0036211

GO:0042551

GO:0042802

GO:0043226

GO:0043353

GO:0043433

GO:0043550

GO:0045445

GO:0045651

GO:0045786

GO:0045842

GO:0045879

GO:0045892

GO:0045930

GO:0045944

GO:0048565

GO:0048667

GO:0048856

GO:0050673

GO:0050680

GO:0050728

GO:0051146

GO:0051172

GO:0051219

GO:0051276

GO:0051301

GO:0051402

GO:0051726

GO:0060090

GO:0060253

GO:0060255

GO:0061629

GO:0061676

GO:0061793

GO:0065003

GO:0071459

GO:0071466

GO:0071901

GO:0080090

GO:0090230

GO:0097284

GO:0097718

GO:0120163

GO:0140014

GO:0140110

GO:0140297

GO:1902948

GO:1903055

GO:1903944

GO:1904028

GO:1904761

GO:2000045

GO:2000134

GO:2000679

GO:2001234

HMNXSV003035055

ILMN_1696591

L41870_at

L49209_s_at

L49218_f_at

L49229_f_at

PH_hs_0024754

TC13000190.hg

g190967_3p_a_at

g4506434_3p_at

Participates

as a member of

RB1 mutants (E2F binding) [nucleoplasm] (Homo sapiens)

as an input of

Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)

Other forms of this molecule

RB1 R661W [nucleoplasm]

RB1 C706F [nucleoplasm]

RB1 N480del [nucleoplasm]

RB1 C706Y [nucleoplasm]

RB1 R661Q [nucleoplasm]

RB1 I703_E737del [nucleoplasm]

RB1 R830_G887del [cytosol]

RB1 K791* [cytosol]

RB1 Q176* [cytosol]

RB1 S114* [cytosol]

RB1 K765* [cytosol]

RB1 W99* [cytosol]

RB1 S149* [cytosol]

RB1 E166* [cytosol]

RB1 G100* [cytosol]

RB1 E125* [cytosol]

RB1 Q121* [cytosol]

RB1 E184* [cytosol]

RB1 E137* [cytosol]

RB1 K745* [cytosol]

RB1 E209* [cytosol]

RB1 S618* [cytosol]

RB1 S463* [cytosol]

RB1 K720* [cytosol]

RB1 K429* [cytosol]

RB1 K652* [cytosol]

RB1 K715* [cytosol]

RB1 K615* [cytosol]

RB1 K412* [cytosol]

RB1 S567* [cytosol]

RB1 S807* [cytosol]

RB1 R467* [cytosol]

RB1 S834* [cytosol]

RB1 S576* [cytosol]

RB1 S758* [cytosol]

RB1 R7Pfs*24 [cytosol]

RB1 S443* [cytosol]

RB1 S648* [cytosol]

RB1 S391* [cytosol]

RB1 S829* [cytosol]

RB1 D32Tfs*33 [cytosol]

RB1 Y651Ifs*7 [cytosol]

RB1 K143Mfs*19 [cytosol]

RB1 V754Sfs*4 [cytosol]

RB1 L44Rfs*4 [cytosol]

RB1 E97Gfs*13 [cytosol]

RB1 I679* [cytosol]

RB1 W195* [cytosol]

RB1 G100Efs*11 [cytosol]

RB1 S648Tfs*4 [cytosol]

RB1 H281Qfs*6 [cytosol]

RB1 Q384* [cytosol]

RB1 S182Yfs*2 [cytosol]

RB1 L343Sfs*3 [cytosol]

RB1 L337Wfs*12 [cytosol]

RB1 S318* [cytosol]

RB1 N627Mfs*16 [cytosol]

RB1 N290Kfs*20 [cytosol]

RB1 F299Lfs*4 [cytosol]

RB1 Q637* [cytosol]

RB1 L76* [cytosol]

RB1 Q762* [cytosol]

RB1 Y655Lfs*4 [cytosol]

RB1 N480Kfs*13 [cytosol]

RB1 Q444* [cytosol]

RB1 T77Lfs*34 [cytosol]

RB1 E747Gfs*3 [cytosol]

RB1 M825* [cytosol]

RB1 L649Ffs*11 [cytosol]

RB1 N472Ifs*6 [cytosol]

RB1 Y813Kfs*12 [cytosol]

RB1 I324Mfs*17 [cytosol]

RB1 M460Ifs*3 [cytosol]

RB1 Y655Ifs*3 [cytosol]

RB1 L769Cfs*41 [cytosol]

RB1 P28Lfs*37 [cytosol]

RB1 E677Dfs*19 [cytosol]

RB1 P370Lfs*10 [cytosol]

RB1 N593Tfs*11 [cytosol]

RB1 K329* [cytosol]

RB1 S249Ffs*22 [cytosol]

RB1 K240* [cytosol]

RB1 L199Ffs*4 [cytosol]

RB1 P253Gfs*5 [cytosol]

RB1 K289* [cytosol]

RB1 S360Pfs*2 [cytosol]

RB1 E323Kfs*9 [cytosol]

RB1 L326* [cytosol]

RB1 P808Kfs*12 [cytosol]

RB1 D584Nfs*2 [cytosol]

RB1 N406Kfs*4 [cytosol]

RB1 K417Wfs*23 [cytosol]

RB1 L797Ffs*18 [cytosol]

RB1 Q266Hfs*2 [cytosol]

RB1 R255* [cytosol]

RB1 K4* [cytosol]

RB1 P641Afs*12 [cytosol]

RB1 V450Sfs*13 [cytosol]

RB1 K524Rfs*28 [cytosol]

RB1 E280* [cytosol]

RB1 M825Ifs*13 [cytosol]

RB1 M761Nfs*21 [cytosol]

RB1 A11Rfs*20 [cytosol]

RB1 E275* [cytosol]

RB1 A635Gfs*6 [cytosol]

RB1 Q266* [cytosol]

RB1 I66Yfs*11 [cytosol]

RB1 Q257* [cytosol]

RB1 P39Rfs*26 [cytosol]

RB1 T664Nfs*4 [cytosol]

RB1 Y771Lfs*24 [cytosol]

RB1 R320Dfs*12 [cytosol]

RB1 E282* [cytosol]

RB1 L277Pfs*9 [cytosol]

RB1 I124* [cytosol]

RB1 N803Tfs*7 [cytosol]

RB1 M386Ifs*11 [cytosol]

RB1 E72Vfs*34 [cytosol]

RB1 R150Kfs*7 [cytosol]

RB1 L743* [cytosol]

RB1 R7Efs*58 [cytosol]

RB1 T140Nfs*6 [cytosol]

RB1 D479Efs*16 [cytosol]

RB1 L199* [cytosol]

RB1 G801* [cytosol]

RB1 S215* [cytosol]

RB1 G435* [cytosol]

RB1 G581* [cytosol]

RB1 L134* [cytosol]

RB1 Y529Lfs*26 [cytosol]

RB1 S816Qfs*10 [cytosol]

RB1 E693Nfs*3 [cytosol]

RB1 D346Rfs*4 [cytosol]

RB1 Q35* [cytosol]

RB1 I806Lfs*10 [cytosol]

RB1 E54* [cytosol]

RB1 L199Yfs*2 [cytosol]

RB1 E48* [cytosol]

RB1 N854* [cytosol]

RB1 W75* [cytosol]

RB1 L389Ffs*3 [cytosol]

RB1 S230* [cytosol]

RB1 H483Sfs*10 [cytosol]

RB1 S842* [cytosol]

RB1 W78* [cytosol]

RB1 G449Efs*8 [cytosol]

RB1 K63* [cytosol]

RB1 K537Nfs*14 [cytosol]

RB1 L206* [cytosol]

RB1 K63Rfs*38 [cytosol]

RB1 P732Lfs*12 [cytosol]

RB1 L158* [cytosol]

RB1 A562Hfs*49 [cytosol]

RB1 E72* [cytosol]

RB1 G540Afs*3 [cytosol]

RB1 N328Ifs*4 [cytosol]

RB1 E843* [cytosol]

RB1 L385* [cytosol]

RB1 E464* [cytosol]

RB1 N123Tfs*2 [cytosol]

RB1 E112Dfs*6 [cytosol]

RB1 E748* [cytosol]

RB1 M148Ifs*8 [cytosol]

RB1 R661* [cytosol]

RB1 Y453* [cytosol]

RB1 K95* [cytosol]

RB1 M484Vfs*8 [cytosol]

RB1 E533* [cytosol]

RB1 G86* [cytosol]

RB1 V654Sfs*14 [cytosol]

RB1 E747* [cytosol]

RB1 E79* [cytosol]

RB1 C553Wfs*53 [cytosol]

RB1 E677* [cytosol]

RB1 K96* [cytosol]

RB1 C102Yfs*7 [cytosol]

RB1 E737* [cytosol]

RB1 E97* [cytosol]

RB1 R579Qfs*29 [cytosol]

RB1 A525Pfs*7 [cytosol]

RB1 L542Kfs*11 [cytosol]

RB1 F482Sfs*10 [cytosol]

RB1 L797* [cytosol]

RB1 P250Afs*16 [cytosol]

RB1 S194Ffs*7 [cytosol]

RB1 N623Qfs*15 [cytosol]

RB1 T9Rfs*56 [cytosol]

RB1 Y813Qfs*10 [cytosol]

RB1 I768Cfs*23 [cytosol]

RB1 L477Mfs*17 [cytosol]

RB1 E675* [cytosol]

RB1 V654Cfs*4 [cytosol]

RB1 F650Lfs*5 [cytosol]

RB1 P39Sfs*10 [cytosol]

RB1 H281Sfs*2 [cytosol]

RB1 E551* [cytosol]

RB1 C61Vfs*4 [cytosol]

RB1 D145Ifs*8 [cytosol]

RB1 M148Hfs*9 [cytosol]

RB1 E837* [cytosol]

RB1 L158Mfs*19 [cytosol]

RB1 L832Ffs*5 [cytosol]

RB1 E440* [cytosol]

RB1 D224Afs*40 [cytosol]

RB1 P822Qfs*4 [cytosol]

RB1 M148Vfs*8 [cytosol]

RB1 L670Cfs*7 [cytosol]

RB1 E465* [cytosol]

RB1 S414Kfs*14 [cytosol]

RB1 K548Nfs*3 [cytosol]

RB1 L135Tfs*5 [cytosol]

RB1 Q207Tfs*5 [cytosol]

RB1 Q384Tfs*11 [cytosol]

RB1 L797Ffs*14 [cytosol]

RB1 P232Rfs*4 [cytosol]

RB1 T497Hfs*22 [cytosol]

RB1 E817* [cytosol]

RB1 N367* [cytosol]

RB1 L809Rfs*17 [cytosol]

RB1 E693* [cytosol]

RB1 K80* [cytosol]

RB1 W99Lfs*11 [cytosol]

RB1 A15Pfs*3 [cytosol]

RB1 Y239Lfs*25 [cytosol]

RB1 D571Lfs*41 [cytosol]

RB1 N186Ifs*6 [cytosol]

RB1 E837Dfs*12 [cytosol]

RB1 E672* [cytosol]

RB1 H483Yfs*9 [cytosol]

RB1 R775Gfs*35 [cytosol]

RB1 E580* [cytosol]

RB1 G617Rfs*36 [cytosol]

RB1 E492* [cytosol]

RB1 A333Ffs*13 [cytosol]

RB1 L564Sfs*47 [cytosol]

RB1 D156Vfs*19 [cytosol]

RB1 C438Vfs*19 [cytosol]

RB1 C278* [cytosol]

RB1 E209Vfs*3 [cytosol]

RB1 T116Lfs*8 [cytosol]

RB1 R698Afs*22 [cytosol]

RB1 V419* [cytosol]

RB1 I415Nfs*13 [cytosol]

RB1 Y173Ffs*11 [cytosol]

RB1 N133Tfs*3 [cytosol]

RB1 M695Rfs*10 [cytosol]

RB1 R418Sfs*9 [cytosol]

RB1 Q689* [cytosol]

RB1 A74Efs*4 [cytosol]

RB1 W99Yfs*5 [cytosol]

RB1 G442Dfs*15 [cytosol]

RB1 N258Efs*11 [cytosol]

RB1 S182Ifs*3 [cytosol]

RB1 Q436* [cytosol]

RB1 Q395Pfs*11 [cytosol]

RB1 Y606Lfs*47 [cytosol]

RB1 E539* [cytosol]

RB1 L317* [cytosol]

RB1 F104Lfs*7 [cytosol]

RB1 E691* [cytosol]

RB1 D340Yfs*5 [cytosol]

RB1 K740Tfs*10 [cytosol]

RB1 H483Ifs*12 [cytosol]

RB1 R611Lfs*43 [cytosol]

RB1 V291Ifs*9 [cytosol]

RB1 N133* [cytosol]

RB1 R334* [cytosol]

RB1 D697Qfs*23 [cytosol]

RB1 L647Ffs*5 [cytosol]

RB1 I723Nfs*28 [cytosol]

RB1 L486Ifs*6 [cytosol]

RB1 S565* [cytosol]

RB1 Y529Tfs*3 [cytosol]

RB1 Q631* [cytosol]

RB1 S318Nfs*13 [cytosol]

RB1 D856Efs*17 [cytosol]

RB1 P595Lfs*16 [cytosol]

RB1 P777Lfs*33 [cytosol]

RB1 G310Dfs*22 [cytosol]

RB1 P250Sfs*20 [cytosol]

RB1 Q850* [cytosol]

RB1 I124Rfs*6 [cytosol]

RB1 Q702* [cytosol]

RB1 E748Dfs*6 [cytosol]

RB1 Q736* [cytosol]

RB1 R798Qfs*4 [cytosol]

RB1 S588Ffs*6 [cytosol]

RB1 K574* [cytosol]

RB1 D156Mfs*19 [cytosol]

RB1 Y771Cfs*23 [cytosol]

RB1 I66Dfs*44 [cytosol]

RB1 Q685* [cytosol]

RB1 E125Kfs*11 [cytosol]

RB1 Y655Lfs*13 [cytosol]

RB1 R828Kfs*10 [cytosol]

RB1 Y659Ifs*4 [cytosol]

RB1 Q846* [cytosol]

RB1 E97Nfs*14 [cytosol]

RB1 Q770* [cytosol]

RB1 C666* [cytosol]

RB1 Q471* [cytosol]

RB1 R71Efs*39 [cytosol]

RB1 Q504* [cytosol]

RB1 R798Tfs*17 [cytosol]

RB1 Q639* [cytosol]

RB1 N328* [cytosol]

RB1 S576Rfs*34 [cytosol]

RB1 T726Nfs*25 [cytosol]

RB1 Q597* [cytosol]

RB1 I532Nfs*57 [cytosol]

RB1 K577Rfs*34 [cytosol]

RB1 R73Sfs*36 [cytosol]

RB1 E413Kfs*4 [cytosol]

RB1 K844Sfs*5 [cytosol]

RB1 A17Pfs*3 [cytosol]

RB1 Q395* [cytosol]

RB1 L523* [cytosol]

RB1 R251* [cytosol]

RB1 L389* [cytosol]

RB1 Q217* [cytosol]

RB1 Q344* [cytosol]

RB1 S634* [cytosol]

RB1 S397* [cytosol]

RB1 S838* [cytosol]

RB1 R556* [cytosol]

RB1 R787* [cytosol]

RB1 G304* [cytosol]

RB1 W516* [cytosol]

RB1 W681* [cytosol]

RB1 E322* [cytosol]

RB1 W563* [cytosol]

RB1 L550* [cytosol]

RB1 R552* [cytosol]

RB1 L512* [cytosol]

RB1 R455* [cytosol]

RB1 R763* [cytosol]

RB1 L779* [cytosol]

RB1 R445* [cytosol]

RB1 R544* [cytosol]

RB1 R320* [cytosol]

RB1 L832* [cytosol]

RB1 Y498* [cytosol]

RB1 Y446* [cytosol]

RB1 Y655* [cytosol]

RB1 E323* [cytosol]

RB1 E364* [cytosol]

RB1 C489* [cytosol]

RB1 G310* [cytosol]

RB1 L335* [cytosol]

RB1 E313* [cytosol]

RB1 E315* [cytosol]

RB1 D479Vfs*14 [cytosol]

RB1 C489Lfs*5 [cytosol]

RB1 Y454* [cytosol]

RB1 E137Rfs*3 [cytosol]

RB1 L676Ffs*16 [cytosol]

RB1 Y728* [cytosol]

RB1 I799Ffs*11 [cytosol]

RB1 D346Vfs*17 [cytosol]

RB1 F514Pfs*8 [cytosol]

RB1 N593Sfs*5 [cytosol]

RB1 T58Yfs*52 [cytosol]

RB1 N522Ifs*2 [cytosol]

RB1 C553Vfs*58 [cytosol]

RB1 P609Cfs*43 [cytosol]

RB1 N269* [cytosol]

RB1 E287Rfs*2 [cytosol]

RB1 E492Lfs*4 [cytosol]

RB1 Q383Nfs*3 [cytosol]

RB1 Y606* [cytosol]

RB1 Y756* [cytosol]

RB1 Y790* [cytosol]

RB1 T502Nfs*17 [cytosol]

RB1 Y709* [cytosol]

RB1 Y749* [cytosol]

hyperphosphorylated RB1 [nucleoplasm]

RB1 [cytosol]

p-S249-RB1 [nucleoplasm]

p-S230-RB1 [nucleoplasm]

p-T356-RB1 [nucleoplasm]

p-T826-RB1 [nucleoplasm]

p-T252-RB1 [nucleoplasm]

p-S807-RB1 [nucleoplasm]

p-T821-RB1 [nucleoplasm]

p-S795-RB1 [nucleoplasm]

p-S612-RB1 [nucleoplasm]

p-S780-RB1 [nucleoplasm]

p-S811-RB1 [nucleoplasm]

p-T373-RB1 [nucleoplasm]

RB1 [nucleoplasm]

p-S788-RB1 [nucleoplasm]

p-S608-RB1 [nucleoplasm]

Modified Residues

Name

Deletion of residues 738 to 775

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
breast cancer	DOID:1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
lung small cell carcinoma	DOID:5409

Cross References

RefSeq

NP_000312.2

OpenTargets

ENSG00000139687

ZINC - Substances

RB_HUMAN

ZINC target

P06400

PRO

P06400

PDB

4ELJ, 1H25, 2AZE, 1AD6, 1O9K, 4ELL, 1GUX, 3POM, 1PJM, 1GH6, 2QDJ, 1N4M, 4CRI, 2R7G, 3N5U

COSMIC

COSV57311580

HPA

ENSG00000139687-RB1

GeneCards

P06400

Ensembl

ENST00000267163, ENSP00000267163, ENSG00000139687

Pharos - Targets

P06400

ZINC - Predictions - Purchasable

RB_HUMAN

Orphanet

15191

Interactors (65)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.97	30
UniProt:P03129 VE7			0.969	28
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.955	18
UniProt:P03070 LT			0.927	9
UniProt:P03255 E1A			0.921	10
UniProt:O00716 E2F3	2	p-E2F3 [nucleoplasm] (R-HSA-187933) E2F3 [nucleoplasm] (R-HSA-68655)	0.822	5
UniProt:Q14209 E2F2	1	E2F2 [nucleoplasm] (R-HSA-68649)	0.78	5
UniProt:P06788 VE7			0.772	4
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.771	5
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.757	6
UniProt:Q14188 TFDP2	1	TFDP2 [nucleoplasm] (R-HSA-1362225)	0.744	5
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.744	6
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.734	5
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.73	5
UniProt:P04020 VE7			0.702	3
UniProt:P03255-2			0.702	3
UniProt:P06464 VE7			0.688	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.67	4
UniProt:Q9Y463 DYR1B			0.67	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.667	3
UniProt:P06465 VE7			0.647	3
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.643	3
UniProt:P52927	1	Hmga2 [nucleoplasm] (R-MMU-1629831)	0.632	5
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.623	3
UniProt:P30285 Cdk4	6	CDK4 [nucleoplasm] (R-MMU-113730) phospho-Cdk4(Thr 286) [nucleoplasm] (R-MMU-182559) Cdk4 [nucleoplasm] (R-MMU-182567) CDK4 [cytosol] (R-MMU-68330) CDK4 [nucleoplasm] (R-MMU-113843) phospho-p-T172-CDK4 [nucleoplasm] (R-MMU-113830)	0.623	2
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.623	4
UniProt:P39880 CUX1	2	CUX1(1-339)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614371) CUX1(1-339)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838991)	0.611	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.61	4
UniProt:Q15329 E2F5	1	E2F5 [nucleoplasm] (R-HSA-68669)	0.609	2
UniProt:Q923E4 Sirt1	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.602	4
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.602	3
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.593	3
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.591	4
UniProt:Q13574-2 DGKZ			0.591	6
UniProt:P03255-1			0.589	2
UniProt:Q3TKT4 Smarca4	2	SMARCA4 [nucleoplasm] (R-MMU-201686) Smarca4 [nucleoplasm] (R-MMU-9727480)	0.573	4
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.571	8
UniProt:Q99708 RBBP8	4	p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138)	0.564	2
UniProt:P03254 E1A			0.558	3
UniProt:O14757 CHEK1	3	CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.558	3
UniProt:P0C6X7-PRO_0000037321 REP			0.556	3
UniProt:Q8VSP9 OSPF			0.544	2
IntAct:EBI-971875 DGKZ-MARCKS-PSD			0.544	2
UniProt:P55345 ANM2			0.544	3
UniProt:P42685 FRK	4	FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142) p-Y387-FRK [cytosol] (R-HSA-8847965)	0.544	3
UniProt:Q9R002 IFI2			0.544	5
UniProt:Q6ZUJ4 CC062			0.527	2
UniProt:Q5H9I0 TFDP3			0.527	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.527	2
UniProt:Q9NQ55 SSF1			0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.525	2
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.524	4
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.524	4
UniProt:Q86500-PRO_0000041225			0.524	3
UniProt:A0MPS7 A0MPS7			0.524	2
UniProt:P07197 NFM			0.524	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.524	4
UniProt:Q00577 PURA			0.524	6
UniProt:O75150 RNF40	1	RNF40 [nucleoplasm] (R-HSA-5689015)	0.508	3
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.499	3
UniProt:P29375 KDM5A	1	KDM5A [nucleoplasm] (R-HSA-3215029)	0.499	2
UniProt:O43524 FOXO3	11	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.499	2
UniProt:Q14653 IRF3	6	p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3(272-427) [cytosol] (R-HSA-9729737) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3 [cytosol] (R-HSA-166251)	0.499	2
UniProt:Q5R372-2 RABGAP1L			0.488	2

Cite Us!