ADORA2B mediated anti-inflammatory cytokines production

Stable Identifier
R-HSA-9660821
Type
Pathway
Species
Homo sapiens
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The natural ligand for adenosine receptor A2B (ADORA2B) is extracellular adenosine (Ad-Rib), formed from the reduction of ATP by ENTDPases. ATP enters the extracellular space in response to parasite infection, tissue injury, apoptosis amongst other stress factors and has chemotactic and excitatory effects (Cekic et al.2016).

The reduction of ATP to Ade Rib is thought to be a regulatory mechanism by which the synthesis of anti inflammatory cytokines is induced. In addition, killing mechanisms are switched off (Figueiredo et al. 2016). Accordingly, increased expression of ADORA2B in monocytes correlates with higher Leishmania donovani parasites loads alongside increment of IL10 production (Vijayamahantesh et al. 2016). Exacerbation of lesion development in L. amazonensis infected mice also correlated with high amounts of Ade Rib (Figueiredo et al. 2016).

Literature References
PubMed ID Title Journal Year
27793266 Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response

Figueiredo, AB, Souza-Testasicca, MC, Afonso, LCC

Biomed J 2016
26748211 Up regulation of A2B adenosine receptor on monocytes are crucially required for immune pathogenicity in Indian patients exposed to Leishmania donovani

Bajegoudar, V, Amit, A, Kumar, S, Dikhit, MR, Jha, PK, Singh, AK, Sinha, KK, Pandey, K, Das, VN, Das, P, Bimal, S

Cytokine 2016
26922909 Purinergic regulation of the immune system

Cekic, C, Linden, J

Nat. Rev. Immunol. 2016
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
cutaneous leishmaniasis 9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
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