Reactome | PolyUb-Misfolded cilia proteins [lysosomal lumen]

PolyUb-Misfolded cilia proteins [lysosomal lumen]

Stable Identifier

R-HSA-9660010

Type

Set [DefinedSet]

Species

Homo sapiens

Compartment

lysosomal lumen

Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Chaperone Mediated Autophagy (Homo sapiens)
  - HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded cilia proteins [lysosomal lumen] (Homo sapiens)
  - HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded cilia proteins [lysosomal lumen] (Homo sapiens)
    - HSPA8:Substrates for CMA [lysosomal lumen] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded cilia proteins [lysosomal lumen] (Homo sapiens)

Participants

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PolyUb-Misfolded Proteins [lysosomal lumen]

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