OGG1beta G12E does not translocate to mitochondria

Stable Identifier
R-HSA-9657051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A missense mutation in OGG1, reported in kidney cancer, leads to substitution of glycine at position 12 with glutamic acid residue, disrupting the mitochondrial targeting sequence at the N-terminus of OGG1. OGG1beta G12E mutant is unable to translocate to the mitochondrion (Audebert et al. 2002). It is uncertain whether OGG1beta participates in the repair of 8-oxoguanine lesions in mitochondrial DNA. While some studies have reported DNA glycosylase activity of OGG1 beta (reviewed by Furihata 2015) and preservation of this activity in OGG1beta G12E mutant (Audebert et al. 2002), other studies have reported lack of DNA glycosylase activity in OGG1beta (Hashiguchi et al. 2004).

Literature References
PubMed ID Title Journal Year
12509224 Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer

Audebert, M, Charbonnier, JB, Boiteux, S, Radicella, JP

DNA Repair (Amst.) 2002
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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