Reactome | OPN1SW binds 11cRAL

OPN1SW binds 11cRAL

Stable Identifier

R-HSA-9656891

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, photoreceptor outer segment membrane

Synonyms

11cRAL binds cone opsins

ReviewStatus

5/5

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Human apo opsin proteins covalently bind the chromophore 11-cis-retinal (11cRAL) via a Schiff base linkage to a lysine residue in the seventh transmembrane alpha helix that is conserved in all known opsins (see review Shichida & Matsuyama 2009). The Schiff base linkage effectively results in an 11-cis-retinyl (11c-retinyl) group covalently linking to a lysine residue of opsins with subsequent loss of water. The three human cone opsins are Long Wavelength Sensitive Opsin (OPN1LW), Short Wavelength Sensitive Opsin (OPN1SW) and Middle Wavelength Sensitive Opsin (OPN1MW), sensing red, blue and green regions of the light spectrum, respectively (Nathans et al. 1986, Nathans et al. 1986b, Oprian et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
1742276	Design, chemical synthesis, and expression of genes for the three human color vision pigments Lee, N, Pelletier, SL, Asenjo, AB, Oprian, DD	Biochemistry	1991
2937147	Molecular genetics of human color vision: the genes encoding blue, green, and red pigments Hogness, DS, Nathans, J, Thomas, D	Science	1986
3485310	Molecular genetics of inherited variation in human color vision Hogness, DS, Nathans, J, Eddy, RL, Shows, TB, Piantanida, TP	Science	1986