p-S621-RAF1 G361A [cytosol]

Stable Identifier
R-HSA-9656092
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf
p-S621-RAF1 G361A [cytosol] icon
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
RAF1, RAF
Chain
chain:1-648
Other Identifiers
11716472_a_at
11748273_a_at
16950848
1917_at
201244_PM_s_at
201244_s_at
2663243
2663245
2663246
2663247
2663248
2663251
2663253
2663258
2663261
2663263
2663270
2663271
2663272
2663273
2663274
2663275
2663278
2663279
2663280
2663281
2663282
2663283
2663284
2663288
2663289
2663290
2663291
2663292
38742_s_at
38743_f_at
42597_at
5894
8085374
A_23_P40952
GO:0000165
GO:0000166
GO:0001678
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005741
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0007010
GO:0007165
GO:0007190
GO:0008285
GO:0008286
GO:0008625
GO:0012501
GO:0014044
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0033138
GO:0035019
GO:0035023
GO:0035773
GO:0035994
GO:0036211
GO:0038133
GO:0042060
GO:0042552
GO:0042802
GO:0042981
GO:0043066
GO:0043154
GO:0043226
GO:0043410
GO:0044342
GO:0045104
GO:0045595
GO:0045944
GO:0046872
GO:0048009
GO:0048011
GO:0048538
GO:0048856
GO:0048870
GO:0060324
GO:0060333
GO:0065003
GO:0071550
GO:0098542
GO:0106310
GO:0140096
GO:1902042
GO:1902531
GO:2000145
HMNXSV003010706
HMNXSV003037375
ILMN_1813489
PH_hs_0039978
TC03001174.hg
X03484_at
g4506400_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
glycine 361 replaced with L-alanine
Coordinate
361
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-alanine.
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
Noonan syndrome DOID:3490 Turner's phenotype, karyotype normal (disorder)
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
ClinGen
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
COSMIC
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (70)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01112 HRAS  20 0.978 30
 UniProt:P63104 YWHAZ  2 0.966 35
 UniProt:P15056 BRAF  20 0.966 72
 UniProt:Q02750 MAP2K1  20 0.96 39
 UniProt:P31946 YWHAB  1 0.955 38
 UniProt:Q04917 YWHAH  1 0.936 27
 UniProt:P61981 YWHAG  1 0.928 25
 UniProt:P27348 YWHAQ  1 0.926 24
 UniProt:P01111 NRAS  20 0.925 12
 UniProt:P62258 YWHAE  1 0.913 24
 UniProt:Q16543 CDC37  1 0.899 20
 UniProt:P31947 SFN  1 0.887 9
 UniProt:P08238 HSP90AB1  6 0.857 17
 UniProt:P36507 MAP2K2  12 0.85 7
 UniProt:P04049 RAF1  20 0.811 6
 UniProt:P30086 PEBP1  1 0.758 10
 UniProt:P07900 HSP90AA1  8 0.744 15
 UniProt:Q3ZCQ8 TIMM50  1 0.738 7
 UniProt:P01116 KRAS  20 0.695 6
 UniProt:P01116-2 KRAS  8 0.676 3
 UniProt:O95816 BAG2  1 0.669 12
 UniProt:P49368 CCT3  1 0.659 8
 UniProt:Q13188 STK3  4 0.645 6
 UniProt:O43852 CALU  3 0.643 4
 UniProt:Q13418 ILK  1 0.643 3
 UniProt:P50990 CCT8  5 0.643 7
 UniProt:P10398 ARAF  4 0.643 4
 UniProt:P62834 RAP1A  4 0.623 2
 UniProt:Q96S96 PEBP4      0.597 4
 UniProt:P11021 HSPA5  6 0.576 5
 UniProt:Q6TCH7 PAQR3  1 0.576 3
 UniProt:P32883 Kras  17 0.573 2
 UniProt:Q8IVT5 KSR1  5 0.564 5
 UniProt:Q9UNE7 STUB1  1 0.564 8
 UniProt:Q15773 MLF2      0.564 4
 UniProt:Q13526 PIN1  2 0.564 2
 UniProt:Q13177 PAK2  11 0.558 2
 UniProt:Q14790 CASP8  8 0.556 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:O39474 O39474      0.556 4
 UniProt:P00533 EGFR  20 0.553 2
 UniProt:Q13362 PPP2R5C  3 0.544 2
 UniProt:P67775 PPP2CA  4 0.544 2
 UniProt:P31749 AKT1  14 0.536 2
 UniProt:P78371 CCT2  3 0.527 6
 UniProt:Q99832 CCT7  1 0.527 6
 UniProt:P30876 POLR2B  1 0.527 2
 UniProt:P50991 CCT4  1 0.527 6
 UniProt:P17066 HSPA6  5 0.527 3
 UniProt:Q9ULX6 AKAP8L  1 0.527 9
 UniProt:P61619 SEC61A1  2 0.527 3
 UniProt:Q9H9S3 SEC61A2  2 0.527 3
 UniProt:Q96AG4 LRC59      0.527 2
 UniProt:P50402 EMD  4 0.527 2
 UniProt:P48643 CCT5  1 0.527 6
 UniProt:O14593 RFXK      0.527 3
 UniProt:Q58FF7 H90B3      0.527 13
 UniProt:P40227 CCT6A  1 0.527 6
 UniProt:P17987 TCP1  1 0.527 5
 UniProt:Q8N163 CCAR2  2 0.527 9
 UniProt:Q53GQ0 HSD17B12  1 0.527 2
 UniProt:O43324 EEF1E1  1 0.527 2
 UniProt:P03495 NS1      0.508 2
 UniProt:Q99933 BAG1  1 0.508 2
 UniProt:O15371 EIF3D  1 0.508 4
 UniProt:P43246 MSH2  3 0.508 2
 UniProt:P28301  3 0.499 2
 UniProt:Q9ESN9-2 MAPK8IP3      0.499 2
 UniProt:P01120  2 0.499 2
 UniProt:P05783 KRT18  1 0.488 5
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