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p-S621-RAF1 G361A [cytosol]
Stable Identifier
R-HSA-9656092
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Phosphorylation of RAF1 mutants (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
RAF1 mutants [cytosol] (Homo sapiens)
p-S621 RAF1 CR3 mutants [cytosol] (Homo sapiens)
p-S621-RAF1 G361A [cytosol] (Homo sapiens)
RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)
RAF1 mutants [cytosol] (Homo sapiens)
p-S621 RAF1 CR3 mutants [cytosol] (Homo sapiens)
p-S621-RAF1 G361A [cytosol] (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
RAF1 mutants [cytosol] (Homo sapiens)
p-S621 RAF1 CR3 mutants [cytosol] (Homo sapiens)
p-S621-RAF1 G361A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04049 RAF1
Gene Names
RAF1, RAF
Chain
chain:1-648
Reference Genes
BioGPS Gene:5894 RAF1
COSMIC (genes):RAF1 RAF1
CTD Gene:5894 RAF1
dbSNP Gene:5894 RAF1
ENSEMBL:ENSG00000132155 RAF1
ENSEMBL_homo_sapiens_GENE:ENSG00000132155.14 RAF1
HGNC:9829 RAF1
KEGG Gene (Homo sapiens):5894 RAF1
Monarch:5894 RAF1
NCBI Gene:5894 RAF1
OMIM:164760 RAF1
UCSC:P04049 RAF1
Reference Transcript
RefSeq:NM_002880.3 RAF1
RefSeq:XM_011533974.2 RAF1
RefSeq:XM_005265355.2 RAF1
Other Identifiers
11716472_a_at
11748273_a_at
16950848
1917_at
201244_PM_s_at
201244_s_at
2663243
2663245
2663246
2663247
2663248
2663251
2663253
2663258
2663261
2663263
2663270
2663271
2663272
2663273
2663274
2663275
2663278
2663279
2663280
2663281
2663282
2663283
2663284
2663288
2663289
2663290
2663291
2663292
38742_s_at
38743_f_at
42597_at
5894
8085374
A_23_P40952
GO:0000165
GO:0000166
GO:0001678
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005741
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0007010
GO:0007165
GO:0007190
GO:0008285
GO:0008286
GO:0008625
GO:0012501
GO:0014044
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0033138
GO:0035019
GO:0035023
GO:0035773
GO:0035994
GO:0036211
GO:0038133
GO:0042060
GO:0042552
GO:0042802
GO:0042981
GO:0043066
GO:0043154
GO:0043226
GO:0043410
GO:0044342
GO:0045104
GO:0045595
GO:0045944
GO:0046872
GO:0048009
GO:0048011
GO:0048538
GO:0048856
GO:0048870
GO:0060324
GO:0060333
GO:0065003
GO:0071550
GO:0098542
GO:0106310
GO:0140096
GO:1902042
GO:1902531
GO:2000145
HMNXSV003010706
HMNXSV003037375
ILMN_1813489
PH_hs_0039978
TC03001174.hg
X03484_at
g4506400_3p_a_at
Participates
as a candidate of
p-S621 RAF1 CR3 mutants [cytosol] (Homo sapiens)
Other forms of this molecule
p-S338,Y340,Y341-RAF1 [cytosol]
p-S338-RAF1 [cytosol]
p-S621-RAF1 S259F [cytosol]
p-S621-RAF1 S257L [cytosol]
p-S621-RAF1 P261L [cytosol]
p-S621-RAF1 N262K [cytosol]
p-S621-RAF1 P261A [cytosol]
p-S621-RAF1 P261S [cytosol]
p-S621-RAF1 S259T [cytosol]
p-S621-RAF1 P261T [cytosol]
p-S621-RAF1 P261R [cytosol]
p-S621-RAF1 S259P [cytosol]
p-S621-RAF1 T260I [cytosol]
p-S621-RAF1 T260R [cytosol]
p-S621-RAF1 V263A [cytosol]
p-S621-RAF1 R256S [cytosol]
p-S621-RAF1 T491I [cytosol]
p-S621-RAF1 D486N [cytosol]
p-S621-RAF1 S427G [cytosol]
p-S621-RAF1 L613V [cytosol]
p-S621-RAF1 G370R [cytosol]
p-S621-RAF1 D486G [cytosol]
p-S621-RAF1 T491R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
hyperphosphorylated RAF1 [plasma membrane]
p-S621-RAF1 [plasma membrane]
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
p-S259,S621-RAF1 [cytosol]
RAF1 [cytosol]
p-Y-RAF1 [cytosol]
p-S621-RAF1 [cytosol]
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
Modified Residues
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
glycine 361 replaced with L-alanine
Coordinate
361
PsiMod
L-alanine residue [MOD:00010]
A protein modification that effectively converts a source amino acid residue to an L-alanine.
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
Disease
Name
Identifier
Synonyms
colorectal cancer
DOID:9256
Noonan syndrome
DOID:3490
Turner's phenotype, karyotype normal (disorder)
Cross References
RefSeq
NP_002871.1
,
XP_011532276.1
,
XP_005265412.1
ZINC - World Drugs
RAF1_HUMAN
Guide to Pharmacology - Targets
2184
ClinGen
CA134687
OpenTargets
ENSG00000132155
ZINC - FDA approved
RAF1_HUMAN
ZINC - Substances
RAF1_HUMAN
ZINC - Biogenic
RAF1_HUMAN
ZINC target
P04049
PRO
P04049
PDB
6XGU
,
6PTW
,
6NTC
,
8T75
,
7JHP
,
7Z38
,
8ATR
,
4FJ3
,
4G0N
,
8AV0
,
1GUA
,
6XHA
,
8CPD
,
6PTS
,
8GAE
,
8CHF
,
9AXA
,
4IEA
,
7Z37
,
8A6F
,
3KUC
,
3OMV
,
9AYA
,
6XI7
,
3NKX
,
8ATS
,
8GFT
,
1C1Y
,
3IQJ
,
8A6H
,
8A68
,
3IQV
,
8EPW
,
3CU8
,
4G3X
,
9AY7
,
6VJJ
,
6XGV
,
3KUD
,
3IQU
,
4IHL
,
6XHB
,
1RFA
,
6NTD
,
8T74
,
8U1L
,
1FAR
,
3O8I
,
1FAQ
,
9AXC
ZINC - Investigational
RAF1_HUMAN
COSMIC
COSV52575934
HPA
ENSG00000132155-RAF1
GeneCards
P04049
Ensembl
ENST00000442415
,
ENSP00000509968
,
ENSP00000401888
,
ENST00000685653
,
ENST00000251849
,
ENST00000691899
,
ENSP00000251849
,
ENSP00000508763
,
ENSG00000132155
Pharos - Targets
P04049
Orphanet
16828
ZINC - Predictions - Purchasable
RAF1_HUMAN
HMDB Protein
HMDBP01153
Interactors (70)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.978
30
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.966
35
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.966
72
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.96
39
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.955
38
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.936
27
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.928
25
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.926
24
UniProt:P01111 NRAS
20
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
NRAS [plasma membrane]
(R-HSA-62725)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
0.925
12
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.913
24
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.899
20
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.887
9
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.857
17
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.85
7
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.811
6
UniProt:P30086 PEBP1
1
PEBP1 [cytosol]
(R-HSA-61487)
0.758
10
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.744
15
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.738
7
UniProt:P01116 KRAS
20
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674814)
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674821)
KRAS A146T [plasma membrane]
(R-HSA-9649623)
KRAS K147E [plasma membrane]
(R-HSA-9651169)
KRAS K147T [plasma membrane]
(R-HSA-9651180)
KRAS V14G [plasma membrane]
(R-HSA-9651295)
KRAS K147N [plasma membrane]
(R-HSA-9651177)
KRAS A146V [plasma membrane]
(R-HSA-9649626)
KRAS A146S [plasma membrane]
(R-HSA-9649621)
KRAS A146P [plasma membrane]
(R-HSA-9649617)
KRAS P34R [plasma membrane]
(R-HSA-9651276)
KRAS P34L [plasma membrane]
(R-HSA-9651269)
KRAS G12A [plasma membrane]
(R-HSA-9649088)
KRAS G12R [plasma membrane]
(R-HSA-9649090)
KRAS G13V [plasma membrane]
(R-HSA-9649644)
KRAS G13S [plasma membrane]
(R-HSA-9649642)
KRAS G13C [plasma membrane]
(R-HSA-9649636)
KRAS G13R [plasma membrane]
(R-HSA-9649639)
KRAS G13A [plasma membrane]
(R-HSA-9649632)
KRAS K5N [plasma membrane]
(R-HSA-9651361)
0.695
6
UniProt:P01116-2 KRAS
8
S-Farn-Me KRAS4B [cytosol]
(R-HSA-9654510)
pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-HSA-9653578)
pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-HSA-9653482)
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649690)
S-Farn KRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649698)
S-Farn proKRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649693)
pro-KRAS4B [cytosol]
(R-HSA-9649686)
S-Farn-Me KRAS4B [plasma membrane]
(R-HSA-9647815)
0.676
3
UniProt:O95816 BAG2
1
BAG2 [cytosol]
(R-HSA-5255445)
0.669
12
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.659
8
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.645
6
UniProt:O43852 CALU
3
CALU [endoplasmic reticulum lumen]
(R-HSA-350695)
p-CALU [endoplasmic reticulum lumen]
(R-HSA-8956931)
CALU [extracellular region]
(R-HSA-350739)
0.643
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.643
7
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.643
4
UniProt:P62834 RAP1A
4
RAP1A [plasma membrane]
(R-HSA-354118)
RAP1A [endosome membrane]
(R-HSA-190053)
RAP1A [cytosol]
(R-HSA-169884)
RAP1A [specific granule membrane]
(R-HSA-6806137)
0.623
2
UniProt:Q96S96 PEBP4
0.597
4
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.576
5
UniProt:Q6TCH7 PAQR3
1
PAQR3 [Golgi membrane]
(R-HSA-5674103)
0.576
3
UniProt:P32883 Kras
17
phospho-p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-MMU-9674821)
Kras [plasma membrane]
(R-MMU-1250483)
S-Farn-Me KRAS4A [plasma membrane]
(R-MMU-9647811)
S-Farn-Me KRAS4B [cytosol]
(R-MMU-9654510)
phospho-pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-MMU-9653482)
phospho-pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-MMU-9653578)
S-Farn-Me PalmS KRAS4A [Golgi membrane]
(R-MMU-9647903)
proKRAS [cytosol]
(R-MMU-9647762)
pro-KRAS4A [cytosol]
(R-MMU-9649683)
S-Farn proKRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649693)
S-Farn-proKRAS [endoplasmic reticulum membrane]
(R-MMU-9647925)
S-Farn-Me KRAS [endoplasmic reticulum membrane]
(R-MMU-9647801)
S-Farn KRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649698)
S-Farn-KRAS [endoplasmic reticulum membrane]
(R-MMU-9647790)
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649690)
S-Farn-Me-PalmS KRAS4A [plasma membrane]
(R-MMU-9647915)
S-Farn-Me KRAS4B [plasma membrane]
(R-MMU-9647815)
0.573
2
UniProt:Q8IVT5 KSR1
5
p-S311,S406 KSR1 [cytosol]
(R-HSA-5672654)
KSR1 [cytosol]
(R-HSA-5672587)
p-S311 KSR1 [cytosol]
(R-HSA-5672652)
p-S311,Y602 KSR1 [plasma membrane]
(R-HSA-5672659)
p-S311,Y602 KSR1 [cytosol]
(R-HSA-5672656)
0.564
5
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.564
8
UniProt:Q15773 MLF2
0.564
4
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.564
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.558
2
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O39474 O39474
0.556
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q13362 PPP2R5C
3
PPP2R5C [nucleoplasm]
(R-HSA-3008946)
p-S337-PPP2R5C [cytosol]
(R-HSA-6811447)
PPP2R5C [cytosol]
(R-HSA-3008954)
0.544
2
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.544
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.536
2
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.527
6
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
6
UniProt:P30876 POLR2B
1
POLR2B [nucleoplasm]
(R-HSA-63504)
0.527
2
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
6
UniProt:P17066 HSPA6
5
HSPA6 [cytosol]
(R-HSA-3371521)
HSPA6 [nucleoplasm]
(R-HSA-5252088)
HSPA6 [secretory granule lumen]
(R-HSA-6801472)
HSPA6 [extracellular region]
(R-HSA-6806500)
HSPA6 [ficolin-1-rich granule lumen]
(R-HSA-6801512)
0.527
3
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.527
9
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.527
3
UniProt:Q9H9S3 SEC61A2
2
SEC61A2 [endoplasmic reticulum membrane]
(R-HSA-444585)
SEC61A2 [phagocytic vesicle membrane]
(R-HSA-1236771)
0.527
3
UniProt:Q96AG4 LRC59
0.527
2
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
6
UniProt:O14593 RFXK
0.527
3
UniProt:Q58FF7 H90B3
0.527
13
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
6
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
5
UniProt:Q8N163 CCAR2
2
DBC1 [nucleoplasm]
(R-HSA-3371479)
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
0.527
9
UniProt:Q53GQ0 HSD17B12
1
HSD17B12 [endoplasmic reticulum membrane]
(R-HSA-548766)
0.527
2
UniProt:O43324 EEF1E1
1
EEF1E1 [cytosol]
(R-HSA-379693)
0.527
2
UniProt:P03495 NS1
0.508
2
UniProt:Q99933 BAG1
1
BAG1 [cytosol]
(R-HSA-5255443)
0.508
2
UniProt:O15371 EIF3D
1
EIF3D [cytosol]
(R-HSA-72548)
0.508
4
UniProt:P43246 MSH2
3
MSH2 R406* [nucleoplasm]
(R-HSA-5575594)
MSH2 [nucleoplasm]
(R-HSA-5357525)
MSH2 GLN601TER [nucleoplasm]
(R-HSA-5577243)
0.508
2
UniProt:P28301
3
LOX(22-168) [extracellular region]
(R-MMU-2022074)
LOX(22-417) [extracellular region]
(R-MMU-2022071)
LOX [extracellular region]
(R-MMU-2022085)
0.499
2
UniProt:Q9ESN9-2 MAPK8IP3
0.499
2
UniProt:P01120
2
RRAS2 [plasma membrane]
(R-SCE-9715189)
RRAS [plasma membrane]
(R-SCE-396959)
0.499
2
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.488
5
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