Reactome | ATF4 binds the DDIT3 promoter

ATF4 binds the DDIT3 promoter

Stable Identifier

R-HSA-9655086

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ATF4 binds a composite CEBP-ATF element in the promoter of the DDIT3 (CHOP, GADD153) gene in response to oxidative stress caused by arsenite (inferred from rat homologs) and amino acid deficiency (Bruhat et al. 2000, Averous et al. 2004, Bruhat et al. 2007, Cherasse et al. 2007). Both arsenite and heme deficiency regulate DDIT3 via EIF2AK1 (HRI) therefore heme deficiency is inferred to produce similar regulation of DDIT3 by ATF4. (Amino acid deficiency regulates DDIT3 via EIF2AK4.) The CEBP binding partner of ATF4 at the CEBP-ATF4 site is unknown. Phosphorylated ATF2 together with ATF4 activate DDIT3 in response to amino acid deficiency (Bruhat et al. 2000, Averous et al. 2004, Bruhat et al. 2007), however the role of ATF2 in heme deficiency is unknown.

Literature References

PubMed ID	Title	Journal	Year
17267404	ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation Bruhat, A, Cherasse, Y, Maurin, AC, Breitwieser, W, Parry, L, Deval, C, Jones, N, Jousse, C, Fafournoux, P	Nucleic Acids Res.	2007
14630918	Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation Averous, J, Bruhat, A, Jousse, C, Carraro, V, Thiel, G, Fafournoux, P	J Biol Chem	2004
17726049	The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP Cherasse, Y, Maurin, AC, Chaveroux, C, Jousse, C, Carraro, V, Parry, L, Deval, C, Chambon, C, Fafournoux, P, Bruhat, A	Nucleic Acids Res.	2007
10982836	Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter Bruhat, A, Jousse, C, Carraro, V, Reimold, AM, Ferrara, M, Fafournoux, P	Mol. Cell. Biol.	2000