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Expression of GRB10
Stable Identifier
R-HSA-9654792
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Expression of GRB10 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The GRB10 gene is transcribed to yield mRNA and the mRNA is translated to yield GRB10 protein (inferred from the mouse homolog). Expression of GRB10 is activated by ATF4 in response to endoplasmic reticulum stress and heme deficiency (inferred from the mouse homolog).
Participants
Input
GRB10 gene [nucleoplasm]
(Homo sapiens)
Output
GRB10 [cytosol]
(Homo sapiens)
Participates
as an event of
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
This event is regulated
Positively by
Regulator
ATF4 [nucleoplasm]
(Homo sapiens)
Inferred From
Expression of Grb10 (Mus musculus)
Authored
May, B (2019-07-19)
Reviewed
Chen, JJ (2019-10-22)
Created
May, B (2019-07-22)
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