Transcription of PPP1R15A

Stable Identifier
R-HSA-9654774
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The PPP1R15A (GADD34) gene is transcribed to yield mRNA (Hollander et al. 1997, Hollander et al. 2001, Oh-Hashi et al. 2001, and inferred from the mouse homolog). Transcription of PPP1R15A is activated by ATF4, which binds the PPP1R15A promoter in response to certain stresses such as endoplasmic reticulum stress, traumatic brain injury, and heme deficiency (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
9153226 Mammalian GADD34, an apoptosis- and DNA damage-inducible gene

Hollander, MC, Zhan, Q, Bae, I, Fornace, AJ

J. Biol. Chem. 1997
11241327 Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors

Hollander, MC, Sheikh, MS, Yu, K, Zhan, Q, Iglesias, M, Woodworth, C, Fornace, AJ

Int. J. Cancer 2001
11163539 Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells

Oh-Hashi, K, Maruyama, W, Isobe, K

Free Radic. Biol. Med. 2001
Participants
Participant Of
This event is regulated
Inferred From
Authored
Reviewed
Created