Reactome | Transcription of PPP1R15A

Transcription of PPP1R15A

Stable Identifier

R-HSA-9654774

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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The PPP1R15A (GADD34) gene is transcribed to yield mRNA (Hollander et al. 1997, Hollander et al. 2001, Oh-Hashi et al. 2001, and inferred from the mouse homolog). Transcription of PPP1R15A is activated by ATF4, which binds the PPP1R15A promoter in response to certain stresses such as endoplasmic reticulum stress, traumatic brain injury, and heme deficiency (inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
11241327	Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors Iglesias, M, Zhan, Q, Yu, K, Fornace, AJ, Sheikh, MS, Woodworth, C, Hollander, MC	Int. J. Cancer	2001
9153226	Mammalian GADD34, an apoptosis- and DNA damage-inducible gene Zhan, Q, Fornace, AJ, Bae, I, Hollander, MC	J. Biol. Chem.	1997
11163539	Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells Oh-Hashi, K, Isobe, K, Maruyama, W	Free Radic. Biol. Med.	2001