ATF4 binds the PPP1R15A (GADD34) promoter

Stable Identifier
R-HSA-9654752
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ATF4 binds a conserved site in the promoter of the PPP1R15A (GADD34) gene in response to endoplasmic reticulum stress and traumatic brain injury (inferred from mouse homologs). ATF4 forms homodimers and heterodimers with other bZip proteins, however the binding partner of ATF4 at the PPP1R15A promoter is unknown. EIF2AK1 activates transcription of PPP1R15A via ATF4 in response to heme deficiency (inferred from mouse homologs).

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