KRAS4B recycles to the plasma membrane

Stable Identifier
R-HSA-9654533
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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ARL2:GTP facilitates the release of the farnesyl group on KRAS4B by promoting a conformational change in PDE6D (Ismail et al, 2011; Schmick et al, 2014). This step is required for the proper localization of KRAS4B at the plasma membrane, but the complete details of this are not fully established. Newly liberated KRAS4B by interact with the negatively charged membrane of recycling endosome and in this way be targeted back to the plasma membrane (Chen et al, 2010; Schmick et al, 2014; reviewed in Schmick et al, 2015

Literature References
PubMed ID Title Journal Year
24725411 KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport

Schmick, M, Vartak, N, Papke, B, Kovacevic, M, Truxius, DC, Rossmannek, L, Bastiaens, PIH

Cell 2014
22002721 Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

Ismail, SA, Chen, YX, Rusinova, A, Chandra, A, Bierbaum, M, Gremer, L, Triola, G, Waldmann, H, Bastiaens, PI, Wittinghofer, A

Nat. Chem. Biol. 2011
25759176 Ras moves to stay in place

Schmick, M, Kraemer, A, Bastiaens, PI

Trends Cell Biol. 2015
21170358 Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1

Chen, B, Jiang, Y, Zeng, S, Yan, J, Li, X, Zhang, Y, Zou, W, Wang, X

PLoS Genet. 2010
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