Reactome | KRAS4B recycles to the plasma membrane

KRAS4B recycles to the plasma membrane

Stable Identifier

R-HSA-9654533

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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ARL2:GTP facilitates the release of the farnesyl group on KRAS4B by promoting a conformational change in PDE6D (Ismail et al, 2011; Schmick et al, 2014). This step is required for the proper localization of KRAS4B at the plasma membrane, but the complete details of this are not fully established. Newly liberated KRAS4B by interact with the negatively charged membrane of recycling endosome and in this way be targeted back to the plasma membrane (Chen et al, 2010; Schmick et al, 2014; reviewed in Schmick et al, 2015

Literature References

PubMed ID	Title	Journal	Year
22002721	Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo Ismail, SA, Chen, YX, Rusinova, A, Chandra, A, Bierbaum, M, Gremer, L, Triola, G, Waldmann, H, Bastiaens, PI, Wittinghofer, A	Nat. Chem. Biol.	2011
24725411	KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport Schmick, M, Vartak, N, Papke, B, Kovacevic, M, Truxius, DC, Rossmannek, L, Bastiaens, PIH	Cell	2014
25759176	Ras moves to stay in place Schmick, M, Kraemer, A, Bastiaens, PI	Trends Cell Biol.	2015
21170358	Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1 Chen, B, Jiang, Y, Zeng, S, Yan, J, Li, X, Zhang, Y, Zou, W, Wang, X	PLoS Genet.	2010