Expression of CHAC1

Stable Identifier
R-HSA-9653894
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of CHAC1
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The CHAC1 gene is transcribed to yield mRNA and the mRNA is translated to yield CHAC1 protein (Crawford et al. 2015, and inferred from the mouse homolog). The transcription factors ATF4, ATF3, and CEBPB (full length) bind ATF/CRE and ACM elements in the CHAC1 promoter and activate transcription of CHAC1 in response to endoplasmic reticulum stress (Crawford et al. 2015). Expression of CHAC1 is also activated by heme deficiency via EIF2AK1 (HRI) and ATF4 (inferred from the mouse homologs). TRIB3 binds the CHAC1 promoter and represses transcription of CHAC1 which leads to decreased cell death during oxidative stress (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
25931127 Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

Mungrue, IN, Kilberg, MS, Shan, J, Sylvester, CF, Higdon, AN, Crawford, RR, Prescott, ET

J. Biol. Chem. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TRIB3:CHAC1 gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
ATF3:ATF4:CEBPB:CHAC1 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Chac1 (Mus musculus)
Authored
May, B  (2019-07-15)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-16)
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