The ATF5 gene is transcribed to yield mRNA (Watatani et al. 2007, Wei et al. 2010, and inferred from the mouse homolog). Transcription of ATF5 is activated by a heterodimer of ATF4 and a CEBP factor in response to proteasome inhibition, heme deficiency, endoplasmic reticulum stress, and amino acid deficiency (inferred from mouse homologs).
Watatani, Y, Kimura, N, Shimizu, YI, Akiyama, I, Tonaki, D, Hirose, H, Takahashi, S, Takahashi, Y
Wei, Y, Ge, Y, Zhou, F, Chen, H, Cui, C, Liu, D, Yang, Z, Wu, G, Gu, J, Jiang, J
ATF4 and DDIT3 (CHOP) bind an CARE element in the promoter of the ATF5 gene and enhance transcription (inferred from mouse homologs).
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