Transcription of ATF5

Stable Identifier
Reaction [omitted]
Homo sapiens
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ATF4 and DDIT3 (CHOP) bind an CARE element in the promoter of the ATF5 gene and enhance transcription (inferred from mouse homologs).

The ATF5 gene is transcribed to yield mRNA (Watatani et al. 2007, Wei et al. 2010, and inferred from the mouse homolog). Transcription of ATF5 is activated by a heterodimer of ATF4 and a CEBP factor in response to proteasome inhibition, heme deficiency, endoplasmic reticulum stress, and amino acid deficiency (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
20423929 Identification and characterization of the promoter of human ATF5 gene

Wei, Y, Ge, Y, Jiang, J, Wu, G, Liu, D, Chen, H, Gu, J, Yang, Z, Cui, C, Zhou, F

J. Biochem. 2010
17140605 Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level

Akiyama, I, Takahashi, S, Shimizu, YI, Hirose, H, Takahashi, Y, Kimura, N, Tonaki, D, Watatani, Y

Life Sci. 2007
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