Reactome | Transcription of ATF5

Transcription of ATF5

Stable Identifier

R-HSA-9653724

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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ATF4 and DDIT3 (CHOP) bind an CARE element in the promoter of the ATF5 gene and enhance transcription (inferred from mouse homologs). The ATF5 gene is transcribed to yield mRNA (Watatani et al. 2007, Wei et al. 2010, and inferred from the mouse homolog). Transcription of ATF5 is activated by a heterodimer of ATF4 and a CEBP factor in response to proteasome inhibition, heme deficiency, endoplasmic reticulum stress, and amino acid deficiency (inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
20423929	Identification and characterization of the promoter of human ATF5 gene Wei, Y, Ge, Y, Jiang, J, Wu, G, Liu, D, Chen, H, Gu, J, Yang, Z, Cui, C, Zhou, F	J. Biochem.	2010
17140605	Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level Akiyama, I, Takahashi, S, Shimizu, YI, Hirose, H, Takahashi, Y, Kimura, N, Tonaki, D, Watatani, Y	Life Sci.	2007