pS181-S-Farn-Me KRAS4B binds BCL2L1

Stable Identifier
R-HSA-9653595
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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At the mitochondrial outer membrane, phosphorylated KRAS4B binds BCL2L1 (also known as BCL-XL) to promote apoptosis (Bivona et al, 2006; reviewed in Ahearn et al, 2018).

Literature References
PubMed ID Title Journal Year
16483930 PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis

Bivona, TG, Quatela, SE, Bodemann, BO, Ahearn, IM, Soskis, MJ, Mor, A, Miura, J, Wiener, HH, Wright, L, Saba, SG, Yim, D, Fein, A, PĂ©rez De Castro, I, Li, C, Thompson, CB, Cox, AD, Philips, MR

Mol. Cell 2006
29311131 Posttranslational Modifications of RAS Proteins

Ahearn, I, Zhou, M, Philips, MR

Cold Spring Harb Perspect Med 2018
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