GABA translocates from cytosol to mitochondrial matrix

Stable Identifier
R-HSA-9653180
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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GABA (gamma-aminobutyrate) is transported across the inner mitochondrial membrane into the mitochondrial matrix. Studies of isolated mitochondria from rat and mouse brains together showed that GABA uptake into isolated mitochondria is energy- and Na+-dependent (Berkich et al. 2007; Kuriyama et al. 1969; Passarella et al. 1984), and Michaeli et al. (2011) have characterized an Arabidopsis protein that mediates mitochondrial GABA uptake, but no mammalian mitochondrial GABA transporter has been identified.

Literature References
PubMed ID Title Journal Year
17847082 Mitochondrial transport proteins of the brain

Berkich, DA, Ola, MS, Cole, J, Sweatt, AJ, Hutson, SM, LaNoue, KF

J. Neurosci. Res. 2007
6743319 Carrier mediated GABA translocation into rat brain mitochondria

Passarella, S, Atlante, A, Barile, M, Quagliariello, E

Biochem. Biophys. Res. Commun. 1984
5359889 Uptake of gamma-aminobutyric acid by mitochondrial and synaptosomal fractions from mouse brain

Kuriyama, K, Weinstein, H, Roberts, E

Brain Res. 1969
21501262 A mitochondrial GABA permease connects the GABA shunt and the TCA cycle, and is essential for normal carbon metabolism

Michaeli, S, Fait, A, Lagor, K, Nunes-Nesi, A, Grillich, N, Yellin, A, Bar, D, Khan, M, Fernie, AR, Turano, FJ, Fromm, H

Plant J. 2011
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