GABA (gamma-aminobutyrate) is transported across the inner mitochondrial membrane into the mitochondrial matrix. Studies of isolated mitochondria from rat and mouse brains together showed that GABA uptake into isolated mitochondria is energy- and Na+-dependent (Berkich et al. 2007; Kuriyama et al. 1969; Passarella et al. 1984), and Michaeli et al. (2011) have characterized an Arabidopsis protein that mediates mitochondrial GABA uptake, but no mammalian mitochondrial GABA transporter has been identified.
Berkich, DA, Ola, MS, Cole, J, Sweatt, AJ, Hutson, SM, LaNoue, KF
Passarella, S, Atlante, A, Barile, M, Quagliariello, E
Kuriyama, K, Weinstein, H, Roberts, E
Michaeli, S, Fait, A, Lagor, K, Nunes-Nesi, A, Grillich, N, Yellin, A, Bar, D, Khan, M, Fernie, AR, Turano, FJ, Fromm, H
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