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ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]
Stable Identifier
R-HSA-9652349
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Drug-mediated inhibition of ERBB2 signaling (Homo sapiens)
ERBB2 binds trastuzumab (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Participants
components
CDC37 [cytosol] (Homo sapiens)
ERBB2:trastuzumab [plasma membrane] (Homo sapiens)
ERBIN [plasma membrane] (Homo sapiens)
HSP90 [cytosol] (Homo sapiens)
Participant Of
output
ERBB2 binds trastuzumab
This entity regulates
Negatively
Trans-autophosphorylation of ERBB2 homodimer
Inferred To
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Caenorhabditis elegans)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Drosophila melanogaster)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Gallus gallus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Mus musculus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Rattus norvegicus)
ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane] (Xenopus tropicalis)
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