Reactome | Intrinsic nucleotide exchange on RAS

Intrinsic nucleotide exchange on RAS

Stable Identifier

R-HSA-9649735

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Inactive RAS:GDP is converted at a low rate to the active GTP-bound state through release of GDP and binding of GTP. This intrinsic GEF activity is weak due to the picomolar affinity of the protein for both nucleotides, but is stimulated by the interaction of RAS proteins with guanine nucleotide exchange factors (Marshall et al, 2012; reviewed in Bourne et al, 1991; Hennig et al, 2015; Pei et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
25781681	Ras activation revisited: role of GEF and GAP systems Markwart, R, Esparza-Franco, MA, Ladds, G, Rubio, I, Hennig, A	Biol. Chem.	2015
1898771	The GTPase superfamily: conserved structure and molecular mechanism McCormick, F, Bourne, HR, Sanders, DA	Nature	1991
28778966	Targeting Ras with Macromolecules Chen, K, Liao, H, Pei, D	Cold Spring Harb Perspect Med	2018
22750304	Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts Marshall, CB, Rottapel, R, Smith, MJ, Gasmi-Seabrook, GM, Meiri, D, Stambolic, V, Ikura, M, Mazhab-Jafari, MT	Methods	2012