Inactive RAS:GDP is converted at a low rate to the active GTP-bound state through release of GDP and binding of GTP. This intrinsic GEF activity is weak due to the picomolar affinity of the protein for both nucleotides, but is stimulated by the interaction of RAS proteins with guanine nucleotide exchange factors (Marshall et al, 2012; reviewed in Bourne et al, 1991; Hennig et al, 2015; Pei et al, 2018).
Markwart, R, Esparza-Franco, MA, Ladds, G, Rubio, I, Hennig, A
McCormick, F, Bourne, HR, Sanders, DA
Chen, K, Liao, H, Pei, D
Marshall, CB, Rottapel, R, Smith, MJ, Gasmi-Seabrook, GM, Meiri, D, Stambolic, V, Ikura, M, Mazhab-Jafari, MT
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