Intrinsic nucleotide exchange on RAS

Stable Identifier
R-HSA-9649735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inactive RAS:GDP is converted at a low rate to the active GTP-bound state through release of GDP and binding of GTP. This intrinsic GEF activity is weak due to the picomolar affinity of the protein for both nucleotides, but is stimulated by the interaction of RAS proteins with guanine nucleotide exchange factors (Marshall et al, 2012; reviewed in Bourne et al, 1991; Hennig et al, 2015; Pei et al, 2018).

Literature References
PubMed ID Title Journal Year
1898771 The GTPase superfamily: conserved structure and molecular mechanism

Bourne, HR, Sanders, DA, McCormick, F

Nature 1991
25781681 Ras activation revisited: role of GEF and GAP systems

Hennig, A, Markwart, R, Esparza-Franco, MA, Ladds, G, Rubio, I

Biol. Chem. 2015
28778966 Targeting Ras with Macromolecules

Pei, D, Chen, K, Liao, H

Cold Spring Harb Perspect Med 2018
22750304 Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

Marshall, CB, Meiri, D, Smith, MJ, Mazhab-Jafari, MT, Gasmi-Seabrook, GM, Rottapel, R, Stambolic, V, Ikura, M

Methods 2012
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Orthologous Events
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