mature p21 RAS binds GDP

Stable Identifier
R-HSA-9649733
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RAS proteins bind GDP with picomolar affinity as part of the RAS:GTP cycle (reviewed in Hennig et al, 2015; Pei et al, 2019; Prior et al, 2012). RAS proteins in the GDP-bound form are inactive. Interaction with guanine nucleotide exchange factors (GEFs) enhances the slow rate of intrinsic GDP dissociation, allowing GTP to bind and activate the protein (reviewed in Henning et al, 2015).

Literature References
PubMed ID Title Journal Year
28778966 Targeting Ras with Macromolecules

Pei, D, Chen, K, Liao, H

Cold Spring Harb Perspect Med 2018
25781681 Ras activation revisited: role of GEF and GAP systems

Hennig, A, Markwart, R, Esparza-Franco, MA, Ladds, G, Rubio, I

Biol. Chem. 2015
22589270 A comprehensive survey of Ras mutations in cancer

Prior, IA, Lewis, PD, Mattos, C

Cancer Res. 2012
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