Reactome | mature p21 RAS binds GDP

mature p21 RAS binds GDP

Stable Identifier

R-HSA-9649733

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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RAS proteins bind GDP with picomolar affinity as part of the RAS:GTP cycle (reviewed in Hennig et al, 2015; Pei et al, 2019; Prior et al, 2012). RAS proteins in the GDP-bound form are inactive. Interaction with guanine nucleotide exchange factors (GEFs) enhances the slow rate of intrinsic GDP dissociation, allowing GTP to bind and activate the protein (reviewed in Henning et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
25781681	Ras activation revisited: role of GEF and GAP systems Markwart, R, Esparza-Franco, MA, Ladds, G, Rubio, I, Hennig, A	Biol. Chem.	2015
28778966	Targeting Ras with Macromolecules Chen, K, Liao, H, Pei, D	Cold Spring Harb Perspect Med	2018
22589270	A comprehensive survey of Ras mutations in cancer Lewis, PD, Mattos, C, Prior, IA	Cancer Res.	2012