Reactome | Mature S-Farn-Me KRAS4B translocates to plasma membrane

Mature S-Farn-Me KRAS4B translocates to plasma membrane

Stable Identifier

R-HSA-9649732

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, plasma membrane

ReviewStatus

5/5

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Mature S-Farn-Me KRAS4B translocates to plasma membrane

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After farnesylation, C-terminal proteolysis and carboxymethylation, KRAS4B translocates to the plasma membrane (reviewed in Gysin et al, 2011). Localization at the plasma membrane is facilitated by an electrostatic interaction between the polybasic residues in the hypervariable region of KRAS4B and the negatively charged phospholipids of the plasma membrane (Hancock et al, 1990; Yeung et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18187657	Membrane phosphatidylserine regulates surface charge and protein localization Silvius, J, Gilbert, GE, Yeung, T, Shi, J, Kapus, A, Grinstein, S	Science	2008
2208277	A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane Hancock, JF, Marshall, CJ, Paterson, H	Cell	1990
21779505	Therapeutic strategies for targeting ras proteins McCormick, F, Salt, M, Young, A, Gysin, S	Genes Cancer	2011