Mature S-Farn-Me KRAS4B translocates to plasma membrane

Stable Identifier
R-HSA-9649732
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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After farnesylation, C-terminal proteolysis and carboxymethylation, KRAS4B translocates to the plasma membrane (reviewed in Gysin et al, 2011). Localization at the plasma membrane is facilitated by an electrostatic interaction between the polybasic residues in the hypervariable region of KRAS4B and the negatively charged phospholipids of the plasma membrane (Hancock et al, 1990; Yeung et al, 2008).

Literature References
PubMed ID Title Journal Year
2208277 A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

Hancock, JF, Paterson, H, Marshall, CJ

Cell 1990
18187657 Membrane phosphatidylserine regulates surface charge and protein localization

Yeung, T, Gilbert, GE, Shi, J, Silvius, J, Kapus, A, Grinstein, S

Science 2008
21779505 Therapeutic strategies for targeting ras proteins

Gysin, S, Salt, M, Young, A, McCormick, F

Genes Cancer 2011
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