EML4 recruits NUDC to mitotic spindle

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EML4 binds to NUDC and recruits it to the kinetochores of the mitotic spindle. The interaction involves the WD40 repeats of EML4 and the C-terminus of NUDC (Chen et al. 2015). Knockdown of EML4 produces similar mitotic defects as the knockdown of NUDC. The knockdown of either of these two genes frequently results in post-mitotic cell death, due to activation of the mitotic spindle checkpoint (Chen et al. 2015, Adib et al. 2019). It is uncertain if PLK1-mediated phosphorylation of NUDC precedes its binding to EML4.

Literature References
PubMed ID Title Journal Year
25789526 EML4 promotes the loading of NUDC to the spindle for mitotic progression

Chen, D, Ito, S, Yuan, H, Hyodo, T, Kadomatsu, K, Hamaguchi, M, Senga, T

Cell Cycle 2015
Participant Of
Orthologous Events
Cite Us!