Reactome | C5AR2 binds anaphylatoxins and thier desArginated derivatives

C5AR2 binds anaphylatoxins and thier desArginated derivatives

Stable Identifier

R-HSA-964811

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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C5AR2 binds anaphylatoxins and thier desArginated derivatives

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C5AR2 (GPR77, C5L2) has been described as a receptor for the chemotactic and inflammatory peptides anaphylatoxin C5a, C4a and C3a and even their des-arginated derivatives. Highest binding affinity was for C3a-desArg, also called Acylation Stimulating Protein (ASP), produced from C3a following arginine removal by carboxypeptidases. Binding of C3a and its derivatives has been disputed (Johswich et al. 2006) leading to suggestions that this receptor may be a C5a scavenger. It is weakly coupled to G(i)-mediated signaling pathways and believed to function primarily as a decoy receptor though it can interact with beta arrestin (Van Lith et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
11773063	The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74) Cain, SA, Monk, PN	J Biol Chem	2002
12540846	The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein Cain, SA, Sniderman, AD, Maslowska, M, Monk, PN, Kalant, D, Cianflone, K	J Biol Chem	2003