Reactome | EML4 binds to microtubules

EML4 binds to microtubules

Stable Identifier

R-HSA-9648017

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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In interphase cells, EML4 associates with cytosolic microtubules. The interaction involves the N-terminal domain of EML4 (Pollmann et al. 2006). EML4 trimerization is needed for microtubule binding (Richards et al. 2015). EML4 binding stabilizes interphase microtubules (Houtman et al. 2007, Adib et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
25740311	Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain Richards, MW, O'Regan, L, Roth, D, Montgomery, JM, Straube, A, Fry, AM, Bayliss, R	Biochem. J.	2015
17196341	Echinoderm microtubule-associated protein like protein 4, a member of the echinoderm microtubule-associated protein family, stabilizes microtubules Houtman, SH, Rutteman, M, De Zeeuw, CI, French, PJ	Neuroscience	2007
31409757	Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression Adib, R, Montgomery, JM, Atherton, J, O'Regan, L, Richards, MW, Straatman, KR, Roth, D, Straube, A, Bayliss, R, Moores, CA, Fry, AM	Sci Signal	2019
16890222	Human EML4, a novel member of the EMAP family, is essential for microtubule formation Pollmann, M, Parwaresch, R, Adam-Klages, S, Kruse, ML, Buck, F, Heidebrecht, HJ	Exp. Cell Res.	2006