EML4 binds to microtubules

Stable Identifier
R-HSA-9648017
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In interphase cells, EML4 associates with cytosolic microtubules. The interaction involves the N-terminal domain of EML4 (Pollmann et al. 2006). EML4 trimerization is needed for microtubule binding (Richards et al. 2015). EML4 binding stabilizes interphase microtubules (Houtman et al. 2007, Adib et al. 2019).

Literature References
PubMed ID Title Journal Year
17196341 Echinoderm microtubule-associated protein like protein 4, a member of the echinoderm microtubule-associated protein family, stabilizes microtubules

Houtman, SH, Rutteman, M, De Zeeuw, CI, French, PJ

Neuroscience 2007
25740311 Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

Richards, MW, O'Regan, L, Roth, D, Montgomery, JM, Straube, A, Fry, AM, Bayliss, R

Biochem. J. 2015
31409757 Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Adib, R, Montgomery, JM, Atherton, J, O'Regan, L, Richards, MW, Straatman, KR, Roth, D, Straube, A, Bayliss, R, Moores, CA, Fry, AM

Sci Signal 2019
16890222 Human EML4, a novel member of the EMAP family, is essential for microtubule formation

Pollmann, M, Parwaresch, R, Adam-Klages, S, Kruse, ML, Buck, F, Heidebrecht, HJ

Exp. Cell Res. 2006
Participants
Participant Of
This event is regulated
Orthologous Events
Authored
Reviewed
Created