EML4 binds to microtubules

Stable Identifier
R-HSA-9648017
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Reaction
Species
Homo sapiens
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In interphase cells, EML4 associates with cytosolic microtubules. The interaction involves the N-terminal domain of EML4 (Pollmann et al. 2006). EML4 trimerization is needed for microtubule binding (Richards et al. 2015). EML4 binding stabilizes interphase microtubules (Houtman et al. 2007, Adib et al. 2019).

Literature References
PubMed ID Title Journal Year
25740311 Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain

O'Regan, L, Richards, MW, Bayliss, R, Fry, AM, Straube, A, Montgomery, JM, Roth, D

Biochem. J. 2015
17196341 Echinoderm microtubule-associated protein like protein 4, a member of the echinoderm microtubule-associated protein family, stabilizes microtubules

De Zeeuw, CI, Houtman, SH, Rutteman, M, French, PJ

Neuroscience 2007
31409757 Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

O'Regan, L, Atherton, J, Straatman, KR, Richards, MW, Bayliss, R, Fry, AM, Straube, A, Moores, CA, Montgomery, JM, Roth, D, Adib, R

Sci Signal 2019
16890222 Human EML4, a novel member of the EMAP family, is essential for microtubule formation

Buck, F, Heidebrecht, HJ, Kruse, ML, Pollmann, M, Parwaresch, R, Adam-Klages, S

Exp. Cell Res. 2006
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