RAS proteins are depalmitoylated

Stable Identifier
R-HSA-9647994
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAS proteins undergo a dynamic palmitoylation and depalmitoylation cycle that regulates their association with membranes and thus their localization and function (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Lin et al, 2017; Ahearn et al, 2018). Depalmitoylation is catalyzed by the acyl-protein thioesterase LYPLA1, also known as APT1, or by members of the ABHD17 family (Dekker et al, 2010; Lin and Conibear, 2015; reviewed in Lin et al, 2017).

Literature References
PubMed ID Title Journal Year
21779505 Therapeutic strategies for targeting ras proteins

Gysin, S, Salt, M, Young, A, McCormick, F

Genes Cancer 2011
20418879 Small-molecule inhibition of APT1 affects Ras localization and signaling

Dekker, FJ, Rocks, O, Vartak, N, Menninger, S, Hedberg, C, Balamurugan, R, Wetzel, S, Renner, S, Gerauer, M, Schölermann, B, Rusch, M, Kramer, JW, Rauh, D, Coates, GW, Brunsveld, L, Bastiaens, PI, Waldmann, H

Nat. Chem. Biol. 2010
2661017 All ras proteins are polyisoprenylated but only some are palmitoylated

Hancock, JF, Magee, AI, Childs, JE, Marshall, CJ

Cell 1989
29311131 Posttranslational Modifications of RAS Proteins

Ahearn, I, Zhou, M, Philips, MR

Cold Spring Harb Perspect Med 2018
28630138 Targeting the Ras palmitoylation/depalmitoylation cycle in cancer

Lin, DTS, Davis, NG, Conibear, E

Biochem. Soc. Trans. 2017
16000296 DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras

Swarthout, JT, Lobo, S, Farh, L, Croke, MR, Greentree, WK, Deschenes, RJ, Linder, ME

J. Biol. Chem. 2005
26701913 ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

Lin, DT, Conibear, E

Elife 2015
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
palmitoyl-(protein) hydrolase activity of LYPLA1 dimer, ABHD17A,B,C [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created
Cite Us!