RAS proteins are depalmitoylated

Stable Identifier
Reaction [transition]
Homo sapiens
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RAS proteins undergo a dynamic palmitoylation and depalmitoylation cycle that regulates their association with membranes and thus their localization and function (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Lin et al, 2017; Ahearn et al, 2018). Depalmitoylation is catalyzed by the acyl-protein thioesterase LYPLA1, also known as APT1, or by members of the ABHD17 family (Dekker et al, 2010; Lin and Conibear, 2015; reviewed in Lin et al, 2017).

Literature References
PubMed ID Title Journal Year
20418879 Small-molecule inhibition of APT1 affects Ras localization and signaling

Waldmann, H, Bastiaens, PI, Rusch, M, Vartak, N, Brunsveld, L, Rocks, O, Coates, GW, Menninger, S, Kramer, JW, Gerauer, M, Balamurugan, R, Renner, S, Rauh, D, Schölermann, B, Dekker, FJ, Wetzel, S, Hedberg, C

Nat. Chem. Biol. 2010
21779505 Therapeutic strategies for targeting ras proteins

McCormick, F, Salt, M, Young, A, Gysin, S

Genes Cancer 2011
2661017 All ras proteins are polyisoprenylated but only some are palmitoylated

Hancock, JF, Childs, JE, Magee, AI, Marshall, CJ

Cell 1989
29311131 Posttranslational Modifications of RAS Proteins

Philips, MR, Zhou, M, Ahearn, I

Cold Spring Harb Perspect Med 2018
28630138 Targeting the Ras palmitoylation/depalmitoylation cycle in cancer

Conibear, E, Davis, NG, Lin, DTS

Biochem. Soc. Trans. 2017
16000296 DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras

Linder, ME, Deschenes, RJ, Croke, MR, Swarthout, JT, Lobo, S, Farh, L, Greentree, WK

J. Biol. Chem. 2005
26701913 ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

Conibear, E, Lin, DT

Elife 2015
Catalyst Activity

palmitoyl-(protein) hydrolase activity of LYPLA1 dimer, ABHD17A,B,C [plasma membrane]

This event is regulated