S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated

Stable Identifier
R-HSA-9647982
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After carboxymethylation, HRAS, NRAS and KRAS4A are palmitoylated on cysteine residues upstream of the CaaX motif (residue C179 in KRAS4A, C181 in NRAS and C181 and C184 in HRAS). KRAS4B lacks upstream cysteine residues and does not undergo palmitoylation (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Ahearn et al, 2018). Palmitoylation is catalyzed by the DHHC9:GOLGA7 complex at the Golgi membrane (Swarthout et al, 2008).

Literature References
PubMed ID Title Journal Year
2661017 All ras proteins are polyisoprenylated but only some are palmitoylated

Hancock, JF, Magee, AI, Childs, JE, Marshall, CJ

Cell 1989
21779505 Therapeutic strategies for targeting ras proteins

Gysin, S, Salt, M, Young, A, McCormick, F

Genes Cancer 2011
29311131 Posttranslational Modifications of RAS Proteins

Ahearn, I, Zhou, M, Philips, MR

Cold Spring Harb Perspect Med 2018
16000296 DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras

Swarthout, JT, Lobo, S, Farh, L, Croke, MR, Greentree, WK, Deschenes, RJ, Linder, ME

J. Biol. Chem. 2005
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein-cysteine S-palmitoyltransferase activity of ZDHHC9:GOLGA7 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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