S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated

Stable Identifier
Reaction [transition]
Homo sapiens
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After carboxymethylation, HRAS, NRAS and KRAS4A are palmitoylated on cysteine residues upstream of the CaaX motif (residue C179 in KRAS4A, C181 in NRAS and C181 and C184 in HRAS). KRAS4B lacks upstream cysteine residues and does not undergo palmitoylation (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Ahearn et al, 2018). Palmitoylation is catalyzed by the DHHC9:GOLGA7 complex at the Golgi membrane (Swarthout et al, 2008).

Literature References
PubMed ID Title Journal Year
21779505 Therapeutic strategies for targeting ras proteins

McCormick, F, Salt, M, Young, A, Gysin, S

Genes Cancer 2011
2661017 All ras proteins are polyisoprenylated but only some are palmitoylated

Hancock, JF, Childs, JE, Magee, AI, Marshall, CJ

Cell 1989
29311131 Posttranslational Modifications of RAS Proteins

Philips, MR, Zhou, M, Ahearn, I

Cold Spring Harb Perspect Med 2018
16000296 DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras

Linder, ME, Deschenes, RJ, Croke, MR, Swarthout, JT, Lobo, S, Farh, L, Greentree, WK

J. Biol. Chem. 2005
Catalyst Activity

protein-cysteine S-palmitoyltransferase activity of ZDHHC9:GOLGA7 [Golgi membrane]

Orthologous Events
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