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mature RAS proteins translocate to plasma membrane
Stable Identifier
R-HSA-9647980
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
,
Golgi membrane
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
mature RAS proteins translocate to plasma membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After farnesylation, C-terminal proteolysis, carboxymethylation and palmitoylation, RAS proteins translocate to the plasma membrane (reviewed in Gysin et al, 2011).
Literature References
PubMed ID
Title
Journal
Year
21779505
Therapeutic strategies for targeting ras proteins
McCormick, F
,
Salt, M
,
Young, A
,
Gysin, S
Genes Cancer
2011
Participants
Input
S-Farn-Me PalmS KRAS4A,HRAS, NRAS [Golgi membrane]
(Homo sapiens)
Output
S-Farn-Me-PalmS KRAS4A, HRAS, NRAS [plasma membrane]
(Homo sapiens)
Participates
as an event of
RAS processing (Homo sapiens)
Orthologous Events
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mature RAS proteins translocate to plasma membrane (Danio rerio)
mature RAS proteins translocate to plasma membrane (Drosophila melanogaster)
mature RAS proteins translocate to plasma membrane (Gallus gallus)
mature RAS proteins translocate to plasma membrane (Mus musculus)
mature RAS proteins translocate to plasma membrane (Rattus norvegicus)
mature RAS proteins translocate to plasma membrane (Sus scrofa)
Authored
Rothfels, K (2019-10-25)
Reviewed
Gavathiotis, E (2020-05-04)
Created
Rothfels, K (2019-06-04)
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