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NMUR1 [plasma membrane]
Stable Identifier
R-HSA-964790
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Neuromedin-U receptor 1, NMUR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
NMUR1,NMUR2:NMU [plasma membrane] (Homo sapiens)
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
NMUR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HB89 NMUR1
Gene Names
NMUR1, GPR66
Chain
chain:1-426
Reference Genes
BioGPS Gene:10316 NMUR1
COSMIC (genes):NMUR1 NMUR1
CTD Gene:10316 NMUR1
dbSNP Gene:10316 NMUR1
ENSEMBL:ENSG00000171596 NMUR1
ENSEMBL_homo_sapiens_GENE:ENSG00000171596.7 NMUR1
HGNC:4518 NMUR1
KEGG Gene (Homo sapiens):10316 NMUR1
Monarch:10316 NMUR1
NCBI Gene:10316 NMUR1
OMIM:604153 NMUR1
UCSC:Q9HB89 NMUR1
Reference Transcript
RefSeq:XM_011510487.2 NMUR1
RefSeq:NM_006056.4 NMUR1
Other Identifiers
10316
11740639_at
11748508_a_at
11752490_x_at
11753347_a_at
16909532
221383_PM_at
221383_at
2603543
2603545
2603546
2603547
2603548
2603549
2603552
2603553
2603555
8059720
A_23_P209700
GO:0001607
GO:0003012
GO:0004930
GO:0005886
GO:0006821
GO:0006939
GO:0007165
GO:0007186
GO:0007200
GO:0007218
GO:0008188
GO:0016020
GO:0019722
GO:0023052
GO:0042924
GO:0050850
GO:0060089
HMNXSV003002443
ILMN_1729287
PH_hs_0013297
TC02002865.hg
g5174442_3p_at
Participates
as a member of
NMUR1,NMUR2 [plasma membrane] (Homo sapiens)
Inferred To
Homologues of NMUR1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of NMUR1 [plasma membrane]
(Drosophila melanogaster)
PK2-R1 [plasma membrane]
(Drosophila melanogaster)
nmur-1 [plasma membrane]
(Caenorhabditis elegans)
nmur-2 [plasma membrane]
(Caenorhabditis elegans)
nmur1 [plasma membrane]
(Xenopus tropicalis)
npr-20 [plasma membrane]
(Caenorhabditis elegans)
PK1-R [plasma membrane]
(Drosophila melanogaster)
CapaR [plasma membrane]
(Drosophila melanogaster)
NMUR1 [plasma membrane]
(Bos taurus)
NMUR1 [plasma membrane]
(Caenorhabditis elegans)
NMUR1 [plasma membrane]
(Canis familiaris)
NMUR1 [plasma membrane]
(Gallus gallus)
NMUR1 [plasma membrane]
(Sus scrofa)
Nmur1 [plasma membrane]
(Mus musculus)
Nmur1 [plasma membrane]
(Rattus norvegicus)
PK2-R2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011508789.1
,
NP_006047.3
Guide to Pharmacology - Targets
298
OpenTargets
ENSG00000171596
HPA
ENSG00000171596-NMUR1
ZINC - Substances
NMUR1_HUMAN
GeneCards
Q9HB89
ZINC target
Q9HB89
Ensembl
ENSP00000305877
,
ENSG00000171596
,
ENST00000305141
PRO
Q9HB89
Pharos - Targets
Q9HB89
ZINC - Predictions - Purchasable
NMUR1_HUMAN
PDB
7W53
,
7W56
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