Addition of GlcNAc to the glycan on the A arm

Stable Identifier
R-HSA-964768
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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This is the first committed step in the synthesis of complex and hybrid N-glycans and is specific to multicellular organisms (Kumar et al, 1990; Hull et al, 1991). Hybri N-glycans are important for inter-cellular interactions and therefore during embryonic development of multicellular organisms, and it is probable that these pathways have evolved just before the emergence of multicellular organisms. Support for this hypothesis is provided by the phenomena of CDG and by the effects of null mutations in C.elegans.

Literature References
PubMed ID Title Journal Year
1702225 Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation

Kumar, R, Yang, J, Larsen, RD, Stanley, P

Proc Natl Acad Sci U S A 1990
1827260 Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene

Hull, E, Sarkar, M, Spruijt, MP, Höppener, JW, Dunn, R, Schachter, H

Biochem Biophys Res Commun 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity of MGAT1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created