Addition of GlcNAc to the glycan on the A arm

Stable Identifier
Reaction [transition]
Homo sapiens
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This is the first committed step in the synthesis of complex and hybrid N-glycans and is specific to multicellular organisms (Kumar et al, 1990; Hull et al, 1991). Hybri N-glycans are important for inter-cellular interactions and therefore during embryonic development of multicellular organisms, and it is probable that these pathways have evolved just before the emergence of multicellular organisms. Support for this hypothesis is provided by the phenomena of CDG and by the effects of null mutations in C.elegans.

Literature References
PubMed ID Title Journal Year
1827260 Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene

Höppener, JW, Hull, E, Spruijt, MP, Schachter, H, Dunn, R, Sarkar, M

Biochem Biophys Res Commun 1991
1702225 Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation

Stanley, P, Larsen, RD, Yang, J, Kumar, R

Proc Natl Acad Sci U S A 1990
Catalyst Activity

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity of MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Orthologous Events
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