Reactome | Addition of GlcNAc to the glycan on the A arm

Addition of GlcNAc to the glycan on the A arm

Stable Identifier

R-HSA-964768

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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Addition of GlcNAc to the glycan on the A arm

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This is the first committed step in the synthesis of complex and hybrid N-glycans and is specific to multicellular organisms (Kumar et al, 1990; Hull et al, 1991). Hybri N-glycans are important for inter-cellular interactions and therefore during embryonic development of multicellular organisms, and it is probable that these pathways have evolved just before the emergence of multicellular organisms. Support for this hypothesis is provided by the phenomena of CDG and by the effects of null mutations in C.elegans.

Literature References

PubMed ID	Title	Journal	Year
1827260	Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene Hull, E, Sarkar, M, Spruijt, MP, Höppener, JW, Dunn, R, Schachter, H	Biochem Biophys Res Commun	1991
1702225	Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation Kumar, R, Yang, J, Larsen, RD, Stanley, P	Proc Natl Acad Sci U S A	1990

Participants

Input

Output

Participates

as an event of

N-glycan trimming and elongation in the cis-Golgi (Homo sapiens)

Catalyst Activity

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity of MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Physical Entity

MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Activity

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0003827)

Orthologous Events

Addition of GlcNAc to the glycan on the A arm (Bos taurus)

Addition of GlcNAc to the glycan on the A arm (Caenorhabditis elegans)

Addition of GlcNAc to the glycan on the A arm (Danio rerio)

Addition of GlcNAc to the glycan on the A arm (Dictyostelium discoideum)

Addition of GlcNAc to the glycan on the A arm (Drosophila melanogaster)

Addition of GlcNAc to the glycan on the A arm (Gallus gallus)

Addition of GlcNAc to the glycan on the A arm (Mus musculus)