GSDME (1-270) binds PIPs

Stable Identifier
R-HSA-9647660
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Gasdermin E (GSDME/DFNA5) cleavage at D270 by caspase‑3 (CASP3) or by granzyme B (GZMB ) liberates the N‑terminal fragment of GSDME (GSDME(1-270)), which moves to the plasma membrane where it strongly binds to inner leaflet lipids such as phosphatidylinositol (4,5)‑bisphosphate (Rogers C et al. 2017; Wang Y et al. 2017). Residues 1–56 of GSDME include 19 hydrophobic ones thought to be involved in membrane targeting and penetration (Rogers C et al. 2017). The N‑terminal fragment of GSDME is thought to induce secondary necrosis/pyroptosis by forming pores in the plasma membrane (Rogers C et al. 2017; Wang Y et al. 2017).

Literature References
PubMed ID Title Journal Year
28045099 Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Rogers, C, Fernandes-Alnemri, T, Mayes, L, Alnemri, D, Cingolani, G, Alnemri, ES

Nat Commun 2017
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