Gasdermin D (GSDMD) is a member of the gasdermin (GSDM) protein family, which is processed by inflammatory caspases and cleaved into an N‐terminal (GSDMD(1-275)) and a C‐terminal (GSDMD (276-484)) fragments (Shi J et al, 2015). Once GSDMD is cleaved, the N-terminal fragment of GSDMD (1-275) targets and permeabilizes cellular membranes by assembling transmembrane pores (Ding J et al, 2016; Liu X et al, 2016; Sborgi L et al, 2016). High‐resolution (≤ 2 nm) atomic force microscopy (AFM) showed that GSDMD N-terminus inserts into various lipid membranes (Mulvihill E et al. 2018). Once inserted, the N-terminal fragment of GSDMD assembles arc‐, slit‐, and ring‐shaped oligomers, which eventually incorporate additional oligomers and transform into larger thermodynamically stable ring‐shaped oligomers (Mulvihill E et al. 2018).