PolyUb-Misfolded proteins bind vimentin to form aggresome

Stable Identifier
R-HSA-9646679
Type
Reaction [binding]
Species
Homo sapiens
Compartment
microtubule organizing center
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PolyUb-Misfolded proteins bind vimentin to form aggresome
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Dynein motor complex drives the multi-ubiquitinated misfolded proteins along the microtubule towards the microtubule organizing center. Here, intermediate filament proteins such as vimentin (VIM) are redistributed to ensheath misfolded proteins to form the aggresome (Johnston JA et al. 1998). Subsequently, the aggresome is removed with the help of autophagy machinery.

Literature References
PubMed ID Title Journal Year
9864362 Aggresomes: a cellular response to misfolded proteins

Johnston, JA, Ward, CL, Kopito, RR

J. Cell Biol. 1998
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Orthologous Events
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PolyUb-Misfolded proteins bind vimentin to form aggresome (Gallus gallus)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Rattus norvegicus)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Xenopus tropicalis)
Authored
Varusai, TM  (2019-05-23)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2019-05-28)