Dynein motor complex drives the multi-ubiquitinated misfolded proteins along the microtubule towards the microtubule organizing center. Here, intermediate filament proteins such as vimentin (VIM) are redistributed to ensheath misfolded proteins to form the aggresome (Johnston JA et al. 1998). Subsequently, the aggresome is removed with the help of autophagy machinery.
Johnston, JA, Ward, CL, Kopito, RR
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