PolyUb-Misfolded proteins bind vimentin to form aggresome

Stable Identifier
R-HSA-9646679
Type
Reaction [binding]
Species
Homo sapiens
Compartment
microtubule organizing center
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PolyUb-Misfolded proteins bind vimentin to form aggresome
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dynein motor complex drives the multi-ubiquitinated misfolded proteins along the microtubule towards the microtubule organizing center. Here, intermediate filament proteins such as vimentin (VIM) are redistributed to ensheath misfolded proteins to form the aggresome (Johnston JA et al. 1998). Subsequently, the aggresome is removed with the help of autophagy machinery.

Literature References
PubMed ID Title Journal Year
9864362 Aggresomes: a cellular response to misfolded proteins

Johnston, JA, Ward, CL, Kopito, RR

J. Cell Biol. 1998
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Rattus norvegicus)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Xenopus tropicalis)
Authored
Varusai, TM  (2019-05-23)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-05-28)
Cite Us!