PolyUb-Misfolded proteins bind vimentin to form aggresome

Stable Identifier
R-HSA-9646679
Type
Reaction [binding]
Species
Homo sapiens
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Dynein motor complex drives the multi-ubiquitinated misfolded proteins along the microtubule towards the microtubule organizing center. Here, intermediate filament proteins such as vimentin (VIM) are redistributed to ensheath misfolded proteins to form the aggresome (Johnston JA et al. 1998). Subsequently, the aggresome is removed with the help of autophagy machinery.

Literature References
PubMed ID Title Journal Year
9864362 Aggresomes: a cellular response to misfolded proteins

Johnston, JA, Ward, CL, Kopito, RR

J. Cell Biol. 1998
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