mTORC1 binds RHEB:GTP

Stable Identifier
R-HSA-9646468
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RHEB:GTP interacts with mTORC1 and activates the kinase activity of mTORC1 (Long et al. 2005, Tee et al. 2005, Long et al. 2007, Yang et al. 2017). RHEB binds the catalytic domain of the MTOR subunit of the mTORC1 complex (Long et al. 2005, Yang et al. 2017). The interaction of RHEB with mTORC1 is independent of the guanyl nucleotide bound by RHEB while the activation of MTOR is dependent on GTP bound to RHEB (Long et al. 2005). The binding of MTOR to RHEB is dependent on amino acid sufficiency (Long et al. 2005) due to association of mTORC1 with the Rag heterodimer at the lysosomal membrane.

Literature References
PubMed ID Title Journal Year
29236692 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Yang, H, Jiang, X, Li, B, Yang, HJ, Miller, M, Yang, A, Dhar, A, Pavletich, NP

Nature 2017
17470430 The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1

Long, X, Lin, Y, Ortiz-Vega, S, Busch, S, Avruch, J

J. Biol. Chem. 2007
15854902 Rheb binds and regulates the mTOR kinase

Long, X, Lin, Y, Ortiz-Vega, S, Yonezawa, K, Avruch, J

Curr Biol 2005
16098514 Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1

Tee, AR, Blenis, J, Proud, CG

FEBS Lett. 2005
15878852 Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

Long, X, Ortiz-Vega, S, Lin, Y, Avruch, J

J. Biol. Chem. 2005
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