Reactome | mTORC1 binds RHEB:GTP

mTORC1 binds RHEB:GTP

Stable Identifier

R-HSA-9646468

Type

Reaction [binding]

Species

Homo sapiens

Compartment

lysosomal membrane

ReviewStatus

5/5

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RHEB:GTP interacts with mTORC1 and activates the kinase activity of mTORC1 (Long et al. 2005, Tee et al. 2005, Long et al. 2007, Yang et al. 2017). RHEB binds the catalytic domain of the MTOR subunit of the mTORC1 complex (Long et al. 2005, Yang et al. 2017). The interaction of RHEB with mTORC1 is independent of the guanyl nucleotide bound by RHEB while the activation of MTOR is dependent on GTP bound to RHEB (Long et al. 2005). The binding of MTOR to RHEB is dependent on amino acid sufficiency (Long et al. 2005) due to association of mTORC1 with the Rag heterodimer at the lysosomal membrane.

Literature References

PubMed ID	Title	Journal	Year
17470430	The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1 Long, X, Lin, Y, Ortiz-Vega, S, Busch, S, Avruch, J	J. Biol. Chem.	2007
29236692	Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 Yang, H, Jiang, X, Li, B, Yang, HJ, Miller, M, Yang, A, Dhar, A, Pavletich, NP	Nature	2017
15854902	Rheb binds and regulates the mTOR kinase Long, X, Lin, Y, Ortiz-Vega, S, Yonezawa, K, Avruch, J	Curr Biol	2005
16098514	Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1 Tee, AR, Blenis, J, Proud, CG	FEBS Lett.	2005
15878852	Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency Long, X, Ortiz-Vega, S, Lin, Y, Avruch, J	J. Biol. Chem.	2005