Dynein motors transport misfolded proteins

Stable Identifier
R-HSA-9646383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
microtubule organizing center, cytosol
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Dynein motors transport misfolded proteins
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Misfolded proteins are transported from the microtubule to the microtubule-organizing center (MTOC) in a dynein-mediated mechanism. Dynein motors carry the cargo along the microtubules from the plus end to the minus end (Garcia Mata R et al. 1999). Confirmatory experiments were performed in grivet cell lines.

Literature References
PubMed ID Title Journal Year
10491388 Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

García-Mata, R, Bebök, Z, Sorscher, EJ, Sztul, ES

J. Cell Biol. 1999
Participants
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Output
Participant Of
hasEvent
Inferred From
Dynein motors transport misfolded proteins (Cercopithecus aethiops)
Authored
Varusai, TM  (2019-05-23)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2019-05-23)