PolyUb-Misfolded Proteins:HDAC6 bind dynein motor

Stable Identifier
R-HSA-9646348
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
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Histone deacetylase 6 (HDAC6) plays a key role in the removal of misfolded proteins when the proteosome system is dysregulated. HDAC6 associates with poly-ubiquitinated misfolded proteins and also to the dynein motor system. Subsequently, this complex of HDAC6,misfolded proteins and dynein motor form aggresomes (Kawaguchi Y et al. 2003).
Literature References
PubMed ID Title Journal Year
14675537 The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Kawaguchi, Y, Kovacs, JJ, McLaurin, A, Vance, JM, Ito, A, Yao, TP

Cell 2003
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Orthologous Events
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Dictyostelium discoideum)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Mus musculus)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Plasmodium falciparum)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Rattus norvegicus)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Sus scrofa)
Authored
Varusai, TM  (2019-05-07)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-05-23)
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