PolyUb-Misfolded Proteins:HDAC6 bind dynein motor

Stable Identifier
R-HSA-9646348
Type
Reaction [binding]
Species
Homo sapiens
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Histone deacetylase 6 (HDAC6) plays a key role in the removal of misfolded proteins when the proteosome system is dysregulated. HDAC6 associates with poly-ubiquitinated misfolded proteins and also to the dynein motor system. Subsequently, this complex of HDAC6,misfolded proteins and dynein motor form aggresomes (Kawaguchi Y et al. 2003).

Literature References
PubMed ID Title Journal Year
14675537 The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

Kawaguchi, Y, Kovacs, JJ, McLaurin, A, Vance, JM, Ito, A, Yao, TP

Cell 2003
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